Advances in Clinical and Experimental Medicine

Title abbreviation: Adv Clin Exp Med
JCR Impact Factor (IF) – 2.1
5-Year Impact Factor – 2.2
Scopus CiteScore – 3.4 (CiteScore Tracker 3.7)
Index Copernicus  – 161.11; MNiSW – 70 pts

ISSN 1899–5276 (print)
ISSN 2451-2680 (online)
Periodicity – monthly

Download original text (PL)

Advances in Clinical and Experimental Medicine

2006, vol. 15, nr 3, May-June, p. 505–511

Publication type: review article

Language: Polish

Swoista odporność humoralna a chlamydie i chlamydofile

Specific Humoral Immunity and Chlamydia and Chlamydophila

Małgorzata Pawlikowska1,, Wiesław Deptuła1,

1 Katedra Mikrobiologii i Immunologii, Wydział Nauk Przyrodniczych, Uniwersytet Szczeciński

Streszczenie

W pracy przedstawiono badania z zakresu swoistej odporności humoralnej u ludzi oraz u zwierząt, w zakażeniu lub immunizacji bakteriami zaliczanymi obecnie do rodzaju Chlamydia sp. (Ch.) i Chlamydophila sp. (Chl.). Zarazki te bytują wewnątrzkomórkowo, występują powszechnie w przyrodzie i są przyczyną wielu schorzeń. Wykazano, że zakażenie lub immunizacja tymi drobnoustrojami wpływa na swoistą odporność humoralną przez zmianę liczby i aktywności limfocytów B oraz stężenia surowiczych i wydzielniczych immunoglobulin, a zmiany te pojawiają się już po kilku godzinach i utrzymują do kilku tygodni od zakażenia lub immunizacji.

Abstract

In the paper studies were presented in the range of specific humoral immunity in humans as well as in animals following infection or immunisation with bacteria of Chlamydia sp. (Ch.) and Chlamydophila sp. (Chl.) genera. Those germs live intracellular, they are very common in environment and they are cause of many disease. Infection or immunisation with the bacteria was shown to affect specific humoral immunity by amount and activity of lymphocytes B and amount of serum and secretory immunoglobulins. The changes appeared already few hours after the infection or immunisation and persisted for a few days – a few decades of days.

Słowa kluczowe

limfocyty B, immunoglobuliny, Chlamydia sp., Chlamydophila sp

Key words

lymphocytes B, immunoglobulins, Chlamydia sp., Chlamydophila sp

References (58)

  1. Everett KD, Bush RM, Andersen AA: Emended description of the order Chlamydiales, proposal of Parachlamydiaceae fam.nov., each containing one monotypic genus, revised taxonomy of the family Chlamydiaceae including a new genus and five new species, and standards for the identification of organisms. Int J Syst Bacteriol 1999, 49, 415–440.
  2. Deptuła W, Pawlikowska M, Travniček M: Nowe dane na temat systematyki chlamydii. Post Mikrobiol 2002, 41, 71–83.
  3. Pawlikowska M: Kształtowanie się wybranych parametrów odporności u królików immunizowanych różnymi szczepami Chlamydia sp. Praca doktorska, Wydział Nauk Przyrodniczych, Uniwersytet Szczeciński 2003.
  4. Kelly KA: Cellular immunity and Chlamydia genital infection: induction, recruitment, and effector mechanisms. Int Rev Immunol 2003, 22, 3–41.
  5. Bard J, Levitt D: Chlamydia trachomatis stimulates human peripheral blood B lymphocytes to proliferate and secrete polyclonal immunoglobulins in vitro. Infect Immun 1984, 43, 84–92.
  6. Bard J, Levitt D: Chlamydia trachomatis (L2 serovar) binds to distinct subpopulations of human peripheral blood leukocytes. Clin Immunol Immunopathol 1986, 38, 150–160.
  7. Buendia AJ, Sanchez J, Del Rio L, Garces B, del Carmen Gallego M, Caro MR, Bernabe A, Salinas J: Differences in the immune response against ruminant chlamydial strains in a murine model. Vet Res 1999, 30, 495–507.
  8. Buxton D, Barlow RM, Finlayson J, Anderson I, Mackellar A: Observation on the pathogenesis of Chlamydia psittaci infection of pregnant sheep. J Comp Pathol 1990, 102, 221–237.
  9. Buxton D, Anderson IE, Longbottom D, Livingstone M, Wattegedera S, Entrican G: Ovine chlamydial abortion: characterization of the inflammatory immune response in placental tissues. J Comp Path 2002, 127, 133–141.
  10. Del Rio L, Buendia AJ, Sanchez J, Garces B, Caro MR, del Carmen Gallego M, Bernabe A, Cuelo F, Salinas J: Chlamydophila abortus (Chlamydia psittaci serotype 1) clearance is associated with the early recruitment of CD8(+) T cells in a mouse model. J Comp Pathol 2000, 123, 171–181.
  11. Levitt D, Newcomb RW, Beem MO: Excessive numbers and activity of peripheral blood B cells in infants with Chlamydia trachomatis pneumonia. Clin Immunol Immunopathol 1983, 29, 424–432.
  12. Levitt D, Danen R, Bard J: Both species of Chlamydia and two biovars of Chlamydia trachomatis stimulate mouse B lymphocytes. J Immunol 1986, 136, 4249–4254.
  13. McCafferty MC: The development of proliferative response of ovine peripheral blood mononuclear cells to Chlamydia psittaci during pregnancy. Vet Immunol Immunopathol 1994, 41, 173–180.
  14. Maxion HK, Liu W, Chang M−H, Kelly KA: The infecting dose of Chlamydia muridarum modulates the innate immune response and ascending infection. Infect Immun 2004, 72, 6330–6340.
  15. Morrison SG, Su H, Caldwell HD, Morrison RP: Immunity to murine Chlamydia trachomatis genital tract reinfection involves B cells and CD4+ T cell but not CD8+ T cell. Infect Immun 2000, 68, 6979–6987.
  16. Niemczuk K, Bednarek D: Changes in the peripheral leukocyte phenotype of calves in clinical cases of bronchopneumonia complicated with chlamydial co−infectious agent. Pol J Vet Sci 2003, 6, 125–129.
  17. Pawlikowska M, Deptuła W: Lymphocytes and their subpopulations in peripheral blood of rabbits immunised with Chlamydia psittaci – Gočaltovo strain. Pol J Vet Sci 2003, 6, Suppl., 34–36.
  18. Persson K, Bröms M: Chlamydial respiratory infection in childhood and spurious immunoglobulin M. Eur J Clin Microbiol 1986, 5, 581–583.
  19. Ramsey KH, Soderberg LSF, Rank RG: Resolution of chlamydial genital infection in B−cell deficient mice and immunity to reinfection. Infect Immun 1988, 56, 1320–1325.
  20. Barron AL, Rank RG, Moses EB: Immune response in mice infected in the genital tract with mouse pneumonitis agent (Chlamydia trachomatis biovar). Infect Immun 1984, 44, 82–85.
  21. Batteiger BE, Rank RG: Analysis of the humoral immune responses to chlamydial genital infection in guinea pigs. Infect Immun 1987, 55, 1767–1773.
  22. Beem MO, Saxon EM: Respiratory−tract colonization and a distinctive pneumonia syndrome in infants infected with Chlamydia trachomatis. N Engl J Med 1977, 296, 306–310.
  23. Brunham RC, Kuo C−C, Cles L, Holmes KK: Correlation of host immune response with quantitative recovery of Chlamydia trachomatis from the human endocervix. Infect Immun 1983, 39, 1491–1494.
  24. Cevenini R, Rumpianesi F, Donati M, Sarov I: A rapid immunoperoxidase assay for the detection of specific IgG antibodies to Chlamydia trachomatis. J Clin Pathol 1983, 36, 353–356.
  25. Cevenini R, Sarov I, Rumpianesi F, Donati M, Melegs C, Varotti C, la Placa M: Serum specific IgA antibody to Chlamydia trachomatis in patients with chlamydial infections detected by ELISA and an immunofluorescence test. J Clin Pathol 1984, 37, 686–691.
  26. Deptuła W, Ruczkowska J, Szenfeld J, Choroszy−Król I, Travniček M: Immunologicky status u hovadzieho dobytka prirodzene infekovaneho mikroorganizmami Chlamydia trachomatis a Chlamydia psittaci. Veterinarni Med (Praga) 1990, 35, 73–79.
  27. Dyszkiewicz W, Paul M, Chylak J, Jemielity M: Przeciwciała IgG, IgA i IgM przeciwko Ch. pneumoniae u chorych kwalifikowanych do operacyjnego leczenia z powodu choroby wieńcowej serca. Pol Merk Lek 2002, 67, 11–14.
  28. Dong−Ji Z, Yang X, Shen C, Lu H, Murdin A, Brunham RC: Priming with Chlamydia trachomatis major outer membrane protein (MOMP) ISCOM boosting enhances protection and is associated with increased immunoglobulin A and Th1 cellular immune responses. Infect Immun 2000, 68, 3074–3078.
  29. Hanuka N, Glasner M, Sarov I: Detection of IgG and IgA antibodies to Chlamydia trachomatis in sera of patients with chlamydial infections: use of immunoblotting and immunoperoxidase assays. Sex Trans Dis 1988, 15, 93–99.
  30. Hechard C, Grepinet O, Rodolakis A: Protection evaluation against Chlamydophila abortus challenge by DNA vaccination with a dnaK−encoding plasmid in pregnant and non−pregnant mice. Vet Res 2002, 33, 313–326.
  31. Juchau SV, Linscott WD, Schachter J, Jawetz E: Inhibition of antichlamydial IgM antibody by IgG antibody in immunofluorescence tests. J Immunol 1973, 108, 1563–1569.
  32. Krauss H, Semler B, Schmeer M, Sommer M: Imunoglobulin classes and subclasses of antibodies to Chlamydia psittaci and Coxiella burnetti in sheep after vaccination and infection. In: Chlamydia diseases of ruminants. (Ed) Aitken JD, Comm. of the Eur. Communities, Luxemburg 1986, p. 85–96.
  33. Lammert JK: Cytotoxic cells induced after Chlamydia psittaci infection in mice. Infect Immun 1982, 35, 1011–1017.
  34. Landers DV, Erlich K, Sung M, Schachter J: Role of L3T4−bearing T−cell populations in experimental murine chlamydial salpingitis. Infect Immun 1991, 59, 3774–3777.
  35. Maass M, Gieffers J, Krause E, Engel PM, Bartels C, Solbach W: Poor corelation between microimmunofluorescence serology and polymerase chain reaction for detection of vascular Chlamydia pneumoniae infection in coronary artery disease patients. Med Microbiol Immunol 1998, 187, 103–106.
  36. Milon A, Geral MF: Dosage des immunoglobulines seriques dans la per de mise−bas des brebis atteintes de chlamydiose. Rev Med Vet 1978, 129, 983–993.
  37. Morrison RP, Feilzer K, Tumas DB: Gene knock−out mice establish a primary protective role for major histocompatibility complex class II−restricted responses in Chlamydia trachomatis genital tract infection. Infect Immun 1995, 63, 4661–4668.
  38. Murray ES, Charbonnet LT, MacDonald AB: Immunity to chlamydial infections of the eye. I. The role of circulatory and secretory antibodies in resistance to reinfection with guinea pig inclusion conjunctivitis. J Immunol 1973, 110, 1518–1525.
  39. Osser S, Persson K: Postabortal pelvic infection associated with Chlamydia trachomatis and the influence of humoral immunity. Am J Obstet Gynecol 1984, 150, 699–703.
  40. Patel HC, Goh BT, Viswalingam ND, Treharne JD: Interpretation of Chlamydia trachomatis response in chlamydial oculogenital infection. Genitourin Med 1995, 71, 94–97.
  41. Rank RG, Batteiger BE, Soderberg LSF: Susceptibility to reinfection after a primary chlamydial genital infection. Infect Immun 1988, 56, 2243–2249.
  42. Rank RG, Batteiger BE: Protective role of serum antibody in immunity to chlamydial genital infection. Infect Immun 1989, 57, 299–301.
  43. Richmond SJ, Caul EO: Fluorescent antibody studies in chlamydial infections. J Clin Microbiol 1975, 1, 345–352.
  44. Schmeer M, Perez−Martinez JA, Schnorr K, Storz J, Krauss H: Analysis of the IgG response of cattle to natural and experimental chlamydial infections. IV Int Symp Vet Lab Anim Amsterdam 1978, p. 472–475.
  45. Schmeer H, Arens M, Krauss H, Schiefer HG, Weidner W: Enzyme−linked Immunosorbent Assay (ELISA) zum nachweis vin IgGund IgM−Antikoerpern bei Chlamydien−Infektionen bei Menschen. Zbl Bakt Hyg A 1983, 256, 119–131.
  46. Schmeer N, Krauss H, Apel J, Adami M, Müller HP, Schneider W: Analysis of caprine IgG1 and IgG2 subclasses response to Chlamydia psittaci infection and vaccination. Vet Microbiol 1987, 14, 125–135.
  47. Schmeer N, Schnorr K, Perez−Martinez J, Storz J: Dominance of Chlamydia psittaci specific IgG2 subclass in the humoral immune responses of naturally and experimentally infected cattle. Vet Immunol Immunopathol 1987, 15, 311–322.
  48. Semler B: Bestimmung von Immunoglobulin−Klassen und –Subklassen (IgG1, IgG2, IgM) gegen Coxiella burnetti und Chlamydia psittaci bei natürlich infizierten und mit Aborstop FQ® vakzinierten Schafen. Praca dokt., Justus Liebig Universitat, Giessen 1987.
  49. Skaug K, Otnaess A−B, Orstavik I, Jerve F: Chlamydial secretory IgA antibodies in human milk. Acta Path Microbiol Immunol Scand Sect. C 1982, 90, 21–25.
  50. Skaug K, Vik ISS, Qvigstad E, Ulstrup JC, Jerve F: Chlamydial serum IgG antibodies in patients with acute salpingitis measured by an enzyme−linked immunosorbent assay. Acta Path Microbiol Immunol Scand Sect C 1982, 90, 67–71.
  51. Surcel HM, Syrjala H, Leinonen M, Saikku P, Herva E: Cell−mediated immunity to Chlamydia pneumoniae measured as lympohocyte blast transformation in vitro. Infect Immun 1993, 61, 2196–2199.
  52. Suri AK, Guerin B, Humblot P, Thibier M: Effect of infection of the genital tract on the concentration of IgG and albumin in bull serum and semen. Vet Immunol Immunopathol 1986, 13, 273–278.
  53. Travniček M, Kovacova D, Bhide MR, Zubricky P, Cislakova L: Detection of IgG antibodies against Chlamydophila abortus in sheep with reprodutive disorders. Acta Vet Brno 2003, 72, 95–99.
  54. Williams DM, Schachter J, Grubbs B, Sumaya CV: The role of antibody in host defense against the agent of mouse pneumonitis. J Inf Dis 1982, 145, 200–205.
  55. Williams DM, Grubbs B, Schachter J: Primary murine Chlamydia trachomatis pneumonia in B−cell deficient mice. Infect Immun 1987, 55, 2387–2390.
  56. Knitz JC, Hoelzle LE, Affolter P, Zimmermann K, Heinritzi K, Wittenbrik MM: Humorale Immunoantwort von Zuchtsauen nach Impfung mit einer stallspezifischen Chlamydophila abortus – Vakzine. Dtsch Tier Wsch 2003, 110, 369–374.
  57. Zhang D, Yang X, Lu H, Zhong G, Brunham RC: Immunity to Chlamydia trachomatis mouse pneumonitis induced by vaccination with live organisms correlates with early granulocyte−macrophages colony stimulating factor and interleukin−12 production with dendritic cell like maturation. Infect Immun 1999, 67, 1606–1613.
  58. Zhang DJ, Yang X, Shen C, Brunham RC: Characterization of immune reponses following intramuscular DNA immunization with the MOMP gene of Chlamydia trachomatis mouse pneumonitis strain. Immunology 1999, 96, 314–321.