Advances in Clinical and Experimental Medicine

Title abbreviation: Adv Clin Exp Med
JCR Impact Factor (IF) – 1.736
5-Year Impact Factor – 2.135
Index Copernicus  – 168.52
MEiN – 70 pts

ISSN 1899–5276 (print)
ISSN 2451-2680 (online)
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Advances in Clinical and Experimental Medicine

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doi: 10.17219/acem/159531

Publication type: review

Language: English

License: Creative Commons Attribution 3.0 Unported (CC BY 3.0)

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Chodór-Rozwadowska KE, Sawicka M, Morawski S, Lenarczyk R, Kalarus Z, Kukulski T. Lead-related tricuspid regurgitation and ventricle dysfunction: Current management and future perspectives [published online as ahead of print on March 7, 2023]. Adv Clin Exp Med. 2023. doi:10.17219/acem/159531

Lead-related tricuspid regurgitation and ventricle dysfunction: Current management and future perspectives

Karolina Ewa Chodór-Rozwadowska1,2,A,B,D,F, Magdalena Sawicka3,C,D,E,F, Stanisław Morawski4,E,F, Radosław Lenarczyk1,2,E,F, Zbigniew Kalarus1,2,E,F, Tomasz Kukulski1,2,A,D,E,F

1 Doctoral School, Division of Medical Sciences in Zabrze, Medical University of Silesia, Katowice, Poland

2 Department of Cardiology, Silesian Centre for Heart Diseases, Zabrze, Poland

3 Department of Cardiac, Vascular and Endovascular Surgery and Transplantology, Silesian Centre for Heart Diseases, Zabrze, Poland

4 Department of Cardiology, Congenital Heart Diseases and Electrotherapy, Medical University of Silesia, Katowice, Poland


The implantation of cardiac implantable electronic devices (CIEDs) may result in or worsen previously existing tricuspid regurgitation (TR). The prevelence of lead-related tricuspid regurgitation (LRTR) in patients with CIEDs is between 7.2% and 44.7% when the degree of worsening TR is not reported, or from 9.8% and 38% when it is diagnosed as worsening of TR severity by at least 2 grades after a CIED has been implanted. It has been suggested that a CIED lead positioned over or pinning a leaflet may be the main cause of TR in this patient population. The septal and posterior leaflets of the tricuspid valve have been reported to be the most affected by CIED leads. Severe LRTR is related to the development of heart failure (HF) or worsening of previously existing dysfunction; it is also associated with elevated mortality. However, there are no definitive predictors of LRTR development or standardized methods of treatment. Some studies have suggested that imaging-guided lead placement can reduce the occurrence of LRTR. This review summarizes current knowledge concerning the development, evaluation, consequences, and management of LRTR.

Key words

cardiac implantable electronic devices, lead-related tricuspid regurgitation, heart failure

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