Advances in Clinical and Experimental Medicine

Title abbreviation: Adv Clin Exp Med
5-Year IF – 2.0, IF – 1.9, JCI (2024) – 0.43
Scopus CiteScore – 4.3
Q1 in SJR 2024, SJR score – 0.598, H-index: 49 (SJR)
ICV – 161.00; MNiSW – 70 pts
Initial editorial assessment and first decision within 24 h

ISSN 1899–5276 (print), ISSN 2451-2680 (online)
Periodicity – monthly

Download original text (EN)

Advances in Clinical and Experimental Medicine

2018, vol. 27, nr 6, June, p. 787–794

doi: 10.17219/acem/68944

Publication type: original article

Language: English

Download citation:

  • BIBTEX (JabRef, Mendeley)
  • RIS (Papers, Reference Manager, RefWorks, Zotero)

The relationship between event-related potentials, stress perception and personality type in patients with multiple sclerosis without cognitive impairment: A pilot study

Marta Waliszewska-Prosół1,A,B,C,D, Marta Nowakowska-Kotas1,A,B,C,D, Roman Kotas2,B,D, Tomasz Bańkowski3,C, Anna Pokryszko-Dragan1,A,C,E,F, Ryszard Podemski1,E,F

1 Department of Neurology, Wroclaw Medical University, Poland

2 Department of Psychiatry, Regional Specialist Hospital, Legnica, Poland

3 Department of Cardiology, Wroclaw Medical University, Poland

Abstract

Background. The clinical course of multiple sclerosis (MS) can vary significantly among patients and is affected by exogenous and endogenous factors. Among these, stress and personality type have been gaining more attention.
Objectives. The aim of this study was to investigate the parameters of event-related potentials (ERPs) with regards to stress perception and personality type, as well as cognitive performance in MS patients.
Material and Methods. The study group consisted of 30 MS patients and 26 healthy controls. Auditory ERPs were performed in both groups, including an analysis of P300 and N200 response parameters. The Perceived Stress Scale (PSS) was used in the MS group to measure the perception of stress. The D-type Scale (DS14) scale was used to determine the features of Type D personality, characterized by social inhibition and negative affectivity.
Results. The score on the PSS corresponded with a moderate or high level of stress perception in 63% of MS patients, while 23% of patients presented with a Type D personality. P300 latencies were significantly longer (p = 0.001), N200 amplitudes were significantly higher (p = 0.004), and N200 latencies were longer in MS patients than in the controls. Strong positive correlations were found between N200 and P300 amplitudes, as well as between the DS14 and PSS results.
Conclusion. Most MS patients experience moderate to severe stress. ERP abnormalities were found in MS patients who did not have overt cognitive impairment and showed correlations with stress levels and negative affectivity. Event-related potentials may be useful in assessing the influence of stress and emotions on the course of MS.

Key words

multiple sclerosis, event-related potentials, stress perception, personality type

References (41)

  1. Selmaj K. Stwardnienie rozsiane – kryteria diagnostyczne i naturalny przebieg choroby. Pol Przeg Neurol. 2005;1:99–105.
  2. Wolińska A. Psychological stress and multiple sclerosis. Neuropsychiat neuropsychol. 2012;7:184–189.
  3. Strober L, Arnett P. Unemployment among women with multiple sclerosis: The role of coping and perceived stress and support in the workplace. Psychol Health Med. 2015;12:1–9.
  4. Mohr DC, Goodkin DE, Bacchetti P, et al. Psychological stress and the subsequent appearance of new brain MRI lesions in MS. Neurology. 2000;55:55–61.
  5. Polich J. P300 clinical utility and control of variability. J Clin Neurophysiol. 1998;15:14–33.
  6. Polman CH, Reingold SC, Banwell B, et al. Diagnostic criteria for multiple sclerosis: 2010 revisions to the McDonald criteria. Ann Neurol. 2011;69:292–302.
  7. Kurtzke JF. Historical and clinical perspectives of the Expanded Disability Status Scale. Neuroepidemiology. 2008;31:1–9.
  8. Rao S. A Manual for the Brief, Repeatable Battery of Neuropsychological tests in multiple sclerosis. New York, NY: National Multiple Sclerosis Society; 1991.
  9. Smith A. The symbol-digit modalities test: A neuropsychologic test of learning and other cerebral disorders. In: Helmuth J, ed. Learning disorder. Seattle, WA: Special Child Publications; 1968:83–91.
  10. Cohen S, Kamarck T, Mermelstein E. A global measure of perceived stress. J Health Soc Behav. 1983;24:385–396.
  11. Juczyński Z, Ogińska-Bulik N. Narzędzia pomiaru stresu i radzenia sobie ze stresem [in Polish]. Warszawa: Pracownia Testów Psychologicznych; 2009.
  12. Denollet J. DS14: Standard assessment of negative affectivity, social inhibition, and type D personality. Psychosom Med. 2005;67:89–97.
  13. Parmenter BA, Weinstock-Guttman B, Garg N, Munschauer F, Benedict RH. Screening for cognitive impairment in multiple sclerosis using the Symbol Digit Modalities Test. Mult Scler J. 2007;13:52–57.
  14. Duncan C, Barry R, Connolly J, et al. Event-related potentials in clinical research: Guidelines for eliciting, recording, and quantifying mismatch negativity, P300, and N400. Clin Neurophysiol. 2009;120:1883–1908.
  15. Senders A, Bourdette D, Hanes D, Yadav V, Shinto L. Perceived stress in multiple sclerosis: The potential role of mindfulness in health and wellbeing. J Evid Based Complementary Altern Med. 2014;19:104–111.
  16. Artemiadis A, Vervainioti A, Alexopoulos E, Rombos A, Anagnostouli M, Darviri C. Stress management and multiple sclerosis: A randomized controlled trial. Arch Clin Neuropsychol. 2012;27:406–416.
  17. Pritchard M, Elison-Bowers P, Birdsall B. Impact of integrative restoration (iRest) meditation on perceived stress levels in multiple sclerosis and cancer outpatients. Stress Health. 2010;26:233–237.
  18. Ogińska-Bulik N. Type D personality in Poland: Validity and application of the Polish DS14. Pol Psychol Bul. 2009;40:130–136.
  19. Williams L, O’Connor R, Howard S, et al. Type-D personality mechanisms of effect: The role of health-related behavior and social support. J Psychosom Res. 2008;64;63–69.
  20. Kunst M, Bogaerts S, Winkel F. Peer and inmate aggression, Type D personality and post-traumatic stress among Dutch prison workers. Stress Health. 2009;25:387–395.
  21. Schiffer A, Smith O, Pedersen S, Widdershoven J, Denollet J. Type D personality and cardiac mortality in patients with chronic heart failure. Int J Cardiol. 2010;142:230–235.
  22. Nefs G, Speight J, Pouwer F, Pop V, Bot M, Denollet J. Type D personality, suboptimal health behaviors and emotional distress in adults with diabetes: Results from Diabetes MILES–The Netherlands. Diabetes Res Clin Pract. 2015;108:94–105.
  23. Dubayova T, Krokavcova M, Nagyova I, et al. Type D, anxiety and depression in association with quality of life in patients with Parkinson’s disease and patients with multiple sclerosis. Qual Life Res. 2013;22:1353–1360.
  24. Ludowig E, Bien C, Elger C. Two P300 generators in the hippocampal formation. Hippocampus. 2010;20:186–195.
  25. Halgren E, Marinkovic K, Chauvel P. Generators of the late cognitive potentials in auditory and visual oddball tasks. Electroencephalogr Clin Neurophysiol. 1998;106:156–164.
  26. Polich J. Meta-analysis of P300 normative aging studies. Psychophysiology. 1996;33:334–353.
  27. Aminoff J, Goodin D. Long-latency cerebral event-related potentials in multiple sclerosis. J Clin Neurophysiol. 2001;18:372–377.
  28. Elger T, Bethke F, Frese A, et al. Event-related potenctials in different subtypes of multiple sclerosis – A cross-sectional study. J Neurol Sci. 2002;205:35–40.
  29. Pokryszko-Dragan A, Zagrajek M, Słotwiński K, Gruszka E, Bilińska M, Podemski R. Neuropsychological testing and event-related potentials in the assessment of cognitive performance in the patients with multiple sclerosis – A pilot study. Clin Neurol Neurosurg. 2009;111: 503–506.
  30. Kocer B, Unal T, Nazliel B, et al. Evaluating sub-clinical cognitive dysfunction and event-related potentials (P300) in clinically isolated syndrome. Neurol Sci. 2008;29:435–444.
  31. Gil R, Zai L, Neau JP, et al. Event-related auditory evoked potentials and multiple sclerosis. Electroencephalogr Clin Neurophysiol. 1993;88: 182–187.
  32. Pokryszko-Dragan A, Zagrajek M, Slotwinski K, et al. Event-related potentials and cognitive performance in multiple sclerosis patients with fatigue. Neurol Sci. 2016;37(9):1545–1556.
  33. Sundgren M, Nikulin VV, Maurex L, Wahlin L, Piehl F, Brismar T. P300 amplitude and response speed relate to preserved cognitive function in relapsing–remitting multiple sclerosis. Clin Neurophysiol. 2015; 126:689–697.
  34. Rogan M, Staubli U, LeDoux J. Fear conditioning induces associative long-term potentiation in the amygdala. Nature. 1997;390: 604–607.
  35. Maes M, Mihaylova I, Bosmans E. Not in the mind of neurasthenic lazybones but in the cell nucleus: Patients with chronic fatigue syndrome have increased production of nuclear factor kappa beta. Neuro Endocrinol Lett. 2007;28:456–462.
  36. Maes M, Twisk FN, Kubera M, Ringel K. Evidence for inflammation and activation of cell-mediated immunity in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS): Increased interleukin-1, tumor necrosis factor-α, PMN-elastase, lysozyme and neopterin. J Affect Disord. 2012;136:933–939.
  37. Senkowski D, Herrmann C. Effects of task difficulty on evoked gamma activity and ERPs in a visual discrimination task. Clin Neurophysiol. 2002;113:1742–1753.
  38. Duan H, Yuan Y, Yang C, Zhang L, Zhang K, Wu J. Anticipatory processes under academic stress: An ERP study. Brain Cogn. 2015;94: 60–67.
  39. Brown D, Fenwick P, Howard R. The contingent negative variation in a Go/No Go avoidance task: Relationships with personality and subjective state. Int J Psychophysiol. 1989;7:35–45.
  40. Nagai Y, Critchley H, Featherstone E, Fenwick P, Trimble M, Dolan R. Brain activity relating to the contingent negative variation: An fMRI investigation. NeuroImage. 2004;21:1232–1241.
  41. Ansari T, Derakshan N. The neural correlates of cognitive effort in anxiety: Effects on processing efficiency. Biol Psychol. 2011;86:337–348.
© Wroclaw Medical University