Advances in Clinical and Experimental Medicine

Title abbreviation: Adv Clin Exp Med
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Advances in Clinical and Experimental Medicine

2017, vol. 26, nr 9, December, p. 1419–1424

doi: 10.17219/acem/65410

Publication type: original article

Language: English

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Effects of vector ultrasonic system debridement and conventional instrumentation on the levels of TNF-α in gingival crevicular fluid of patients with chronic periodontitis

Osman Fatih Arpağ1,A,D, Ahmet Dağ2,E,F, Bozan Serhat İzol2,B,F, Gülcan Cimitay3,B, Ersin Uysal4,C

1 Department of Periodontology, Faculty of Dentistry, Mustafa Kemal University, Hatay, Turkey

2 Department of Periodontology, Faculty of Dentistry, Dicle University, Diyarbakır, Turkey

3 Central Laboratory, Faculty of Medicine, Dicle University, Diyarbakır, Turkey

4 Vocational High School, Department of Technics Programs, Dicle University, Diyarbakır, Turkey

Abstract

Background. Tumor necrosis factor alpha (TNF-α) is an inflammatory mediator whose levels are increased in the gingival crevicular fluid and blood serum in the case of chronic periodontitis.
Objectives. The aim of this study was to determine the effect of vector ultrasonic system (VUS) on the levels of TNF-α in gingival crevicular fluid (GCF) and the clinical parameters in patients with chronic periodontitis.
Material and Methods. The study protocol was conducted using split-mouth design in 30 patients with chronic periodontitis. VUS and scaling and root planing (S/RP) were applied separately to 2 quadrants, including the upper and the lower jaws. At baseline and after 6 months, clinical parameters including plaque index (PI), gingival index (GI), probing depth (PD), clinical attachment level (CAL) were recorded, and concentrations of TNF-α in GCF were determined by enzyme-linked immunosorbent assay (ELISA). Intergroup comparisons were evaluated by the independent Students’ t-test, and the Pearson correlation was used to determine the relationship between parameters. The level of significance was set at 5%.
Results. Both treatment modalities provided statistically significant improvements in clinical periodontal parameters and TNF-α levels after 6 months (p < 0.05). Also, there were no significant correlations between the TNF-α levels in GCF and the clinical parameters in both treatment group at baseline and at the end of 6 months period (p > 0.05).
Conclusion. The use of the vector ultrasonic system in the non-surgical treatment of chronic periodontitis presents beneficial improvements for the clinical attachment level and the probing pocket depth as well as TNF-α levels in GCF.

Key words

non-surgical periodontal debridement, tumor necrosis factor alpha, chronic periodontitis

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