Advances in Clinical and Experimental Medicine

Title abbreviation: Adv Clin Exp Med
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Advances in Clinical and Experimental Medicine

2017, vol. 26, nr 9, December, p. 1383–1389

doi: 10.17219/acem/65785

Publication type: original article

Language: English

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The usefulness of routinely used malnutrition screening tools in predicting anemia in lung cancer patients

Katarzyna A. Zabłocka-Słowińska1,A,B,C,D, Monika Kosacka2,B, Irena Porębska2,B, Konrad Pawełczyk3,B, Marcin Gołecki2,B, Jadwiga Biernat4,E,F, Halina Grajeta1,E,F

1 Department of Food Science and Nutrition, Wroclaw Medical University, Poland

2 Department and Clinic of Pulmonology and Lung Cancers, Wroclaw Medical University, Poland

3 Department and Clinic of Thoracic Surgery, Wroclaw Medical University, Poland

4 Department of Human Nutrition, Wroclaw University of Environmental and Life Sciences, Poland

Abstract

Background. Anemia and malnutrition are frequently observed during lung cancer development, and the associations between them have been researched. However, no study concerning the utility of routinely used nutritional screening tools in predicting anemia in lung cancer has been performed.
Objectives. The aim of this study was to assess the usefulness of routinely used malnutrition screening tools in predicting anemia in lung cancer patients.
Material and Methods. Eighty-five male patients were recruited to this study. Blood counts, serum iron concentration, total iron binding capacity (TIBC) and serum transferrin saturation (STS), measurements of selected anthropometric parameters, Mini Nutritional Assessment (MNA) and Glasgow Prognostic Score (GPS) were performed for the subjects. To evaluate the differences in the distribution of hematological and iron status parameters according to nutritional status, a t-test (Mann-Whitney U test for non-parametric data) and an analysis of variance (ANOVA) were performed. Tukey's post hoc test was performed for intergroup comparison of parametric data. The sensitivity, specificity, positive and negative predictive values of MNA and GPS were compared to blood counts and biochemical parameters of iron status.
Results. Using the MNA test, we observed that ca. 60% of subjects had deteriorated nutritional status. About half of the patients had inflammation cumulated with malnutrition. A similar part of the subjects had anemia. The MNA test showed a significant difference in the distribution of Hb and Htc, while GPS showed the distribution of Fe and TIBC among lung cancer patients. We did not observe any influence of fat-free mass index (FFMI) on hematological and iron status parameters. The MNA test had very high specificity and positive predictive values (PPV) for all the hematological parameters evaluated as well as GPS for serum Fe concentration and TIBC.
Conclusion. Our data demonstrates that an evaluation of nutritional status with the MNA test can provide additional predictive information regarding anemia, while GPS may do the same with type of anemia in lung cancer patients.

Key words

lung cancer, malnutrition, anemia, MNA, FFMI

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