Advances in Clinical and Experimental Medicine

Title abbreviation: Adv Clin Exp Med
5-Year IF – 2.0, IF – 1.9, JCI (2024) – 0.43
Scopus CiteScore – 4.3
Q1 in SJR 2024, SJR score – 0.598, H-index: 49 (SJR)
ICV – 161.00; MNiSW – 70 pts
Initial editorial assessment and first decision within 24 h

ISSN 1899–5276 (print), ISSN 2451-2680 (online)
Periodicity – monthly

Download original text (EN)

Advances in Clinical and Experimental Medicine

2017, vol. 26, nr 8, November, p. 1275–1281

Publication type: review

Language: English

CCDC26 rs4295627 polymorphisms associated with an increased risk of glioma: A meta-analysis

Jie Zeng1,A,B,C,D, Yueji Luo1,B,C,D, Min Yu2,C,D,E,F, Jianming Li1,B,C, Zhenghai Liu3,A,B,E,F

1 Department of Anatomy, Histology and Embryology, Changsha Medical University, China

2 Department of Pharmacy, Chenzhou No.1 People's Hospital, China

3 Institute of CIinical Anatomy and Reproductive Medicine, University of South China, Hengyang, China

Abstract

Background. Gliomas are the most common primary brain tumor in adults. Many studies have revealed associations between the rs4295627 polymorphism in the coiled-coil domain containing 26 (CCDC26) gene and the risk of glioma. However, the conclusions are still unclear because some studies have reported inconsistent results.
Objectives. The aim of the present meta-analysis was to determine the relationship and quantitatively evaluate the effect of the rs4295627 polymorphism on the risk of glioma.
Material and Methods. Data was extracted from PubMed, EMBASE and Google Scholar, with the most recent search up to December, 2015. Odds ratios (OR) and their 95% CIs were used to evaluate the effect of CCDC26 rs4295627 polymorphisms on glioma. A test of heterogeneity and an assessment of publication bias were also performed.
Results. A total of 11 studies (8292 cases and 12,419 controls) were selected for this meta-analysis. Significant associations were observed in all genetic analysis models (G vs T: OR = 1.26, 95% CI = 1.12–1.43; GG vs TT: OR = 1.72, 95% CI = 1.24–2.39; GT vs TT: OR = 1.33, 95% CI = 1.24–1.42; GG + GT vs TT: OR = 1.36, 95% CI = 1.20–1.53; GG vs GT + TT: OR = 1.65, 95% CI = 1.18–2.29, respectively).
Conclusion. The results of the present study clearly show that the G allele of the rs4295627 polymorphism significantly increases the risk of glioma. Nevertheless, well-designed large-scale studies are needed to further evaluate the effect of the rs4295627 polymorphism on different types or degrees of glioma in different ethnic groups as well as to measure the combined effects on glioma risk.

Key words

meta-analysis, glioma, rs4295627, CCDC26

References (26)

  1. Ricard D, Idbaih A, Ducray F, Lahutte M, Hoang-Xuan K, Delattre JY. Primary brain tumours in adults. Lancet. 2012;379:1984–1996.
  2. Wen PY, Kesari S. Malignant gliomas in adults. N Engl J Med. 2008;359:492–507.
  3. Ahmed R, Oborski MJ, Hwang M, Lieberman FS, Mountz JM. Malignant gliomas: Current perspectives in diagnosis, treatment, and early response assessment using advanced quantitative imaging methods. Cancer Management and Research. 2014;6:149–170.
  4. Kohler BA, Ward E, McCarthy BJ, et al. Annual report to the nation on the status of cancer, 1975–2007, featuring tumors of the brain and other nervous system. J Natl Cancer Inst. 2011;103:714–736.
  5. McNamara S. Treatment of primary brain tumours in adults. Nursing Standard. 2012;27:42–47.
  6. Nazarenko I, Hede SM, He X, et al. Pdgf and pdgf receptors in glioma. Ups J Med Sci. 2012;117:99–112.
  7. Shete S, Hosking FJ, Robertson LB, et al. Genome-wide association study identifies five susceptibility loci for glioma. Nat Gen. 2009;41:899–904.
  8. Safaeian M, Rajaraman P, Hartge P, et al. Joint effects between five identified risk variants, allergy, and autoimmune conditions on glioma risk. Cancer Causes Control. 2013;24:1885–1891.
  9. Yin W, Rossin A, CIifford JL, Gronemeyer H. Co-resistance to retinoic acid and trail by insertion mutagenesis into ram. Oncogene. 2006;25:3735–3744.
  10. Das A, Banik NL, Ray SK. Differentiation decreased telomerase activity in rat glioblastoma c6 cells and increased sensitivity to ifn-gamma and taxol for apoptosis. Neurochem Res. 2007;32:2167–2183.
  11. Jiang M, Zhu K, Grenet J, Lahti JM. Retinoic acid induces caspase-8 transcription via phospho-creb and increases apoptotic responses to death stimuli in neuroblastoma cells. Biochim Biophys Acta. 2008;1783:1055–1067.
  12. Easton DF, Pooley KA, Dunning AM, et al. Genome-wide association study identifies novel breast cancer susceptibility loci. Nature. 2007;447:1087–1093.
  13. Kiemeney LA, Thorlacius S, Sulem P, et al. Sequence variant on 8q24 confers susceptibility to urinary bladder cancer. Nat Genet. 2008;40:1307–1312.
  14. Chen H, Chen Y, Zhao Y, et al. Association of sequence variants on chromosomes 20, 11, and 5 (20q13.33, 11q23.3, and 5p15.33) with glioma susceptibility in a Chinese population. Epidemiol Rev. 2011;173:915–922.
  15. Egan KM, Thompson RC, Nabors LB, et al. Cancer susceptibility variants and the risk of adult glioma in a US case-control study. J Neurooncol. 2011;104:535–542.
  16. Wei XB, Jin TB, Li G, et al. Ccdc26 gene polymorphism and glioblastoma risk in the Han Chinese population. Asian Pacific Journal of Cancer Prevention (APJCP). 2014;15:3629–3633.
  17. Sun L, Tan L, Yang F, et al. Meta-analysis suggests that smoking is associated with an increased risk of early natural menopause. Menopause. 2012;19:126–132.
  18. Di Stefano AL, Enciso-Mora V, Marie Y, et al. Association between glioma susceptibility loci and tumour pathology defines specific molecular etiologies. Neuro-Oncology. 2013;15:542–547.
  19. Melin B, Dahlin AM, Andersson U, et al. Known glioma risk loci are associated with glioma with a family history of brain tumours: A case-control gene association study. Int J Cancer. 2013;132:2464–2468.
  20. Wang SS, Hartge P, Yeager M, et al. Joint associations between genetic variants and reproductive factors in glioma risk among women. Epidemiol Rev. 2011;174:901–908.
  21. Schoemaker MJ, Robertson L, Wigertz A, et al. Interaction between 5 genetic variants and allergy in glioma risk. Epidemiol Rev. 2010;171:1165–1173.
  22. Li S, Jin T, Zhang J, et al. Polymorphisms of treh, il4r and ccdc26 genes associated with risk of glioma. Cancer Epidemiology. 2012;36:283–287.
  23. Munafo MR, Flint J. Meta-analysis of genetic association studies. TIG. 2004;20:439–444.
  24. Jenkins RB, Wrensch MR, Johnson D, et al. Distinct germ line polymorphisms underlie glioma morphologic heterogeneity. Cancer Genet. 2011;204:13–18.
  25. Forsberg BC, van Ginneken JK, Nagelkerke NJ. Cross-sectional household surveys of diarrhoeal diseases: A comparison of data from the control of diarrhoeal diseases and demographic and health surveys programmes. Int J Epidemiol. 1993;22:1137–1145.
  26. Giuffra LA, Risch N. Diminished recall and the cohort effect of major depression: A simulation study. Psychol Med. 1994;24:375–383.
© Wroclaw Medical University