Advances in Clinical and Experimental Medicine

Title abbreviation: Adv Clin Exp Med
5-Year IF – 2.0, IF – 1.9, JCI (2024) – 0.43
Scopus CiteScore – 4.3
Q1 in SJR 2024, SJR score – 0.598, H-index: 49 (SJR)
ICV – 161.00; MNiSW – 70 pts
Initial editorial assessment and first decision within 24 h

ISSN 1899–5276 (print), ISSN 2451-2680 (online)
Periodicity – monthly

Download original text (EN)

Advances in Clinical and Experimental Medicine

2017, vol. 26, nr 7, October, p. 1147–1153

doi: 10.17219/acem/64054

Publication type: review

Language: English

Download citation:

  • BIBTEX (JabRef, Mendeley)
  • RIS (Papers, Reference Manager, RefWorks, Zotero)

Oral cavity health among cystic fibrosis patients: Literature overview

Katarzyna Herman1,A,D,E,F, Małgorzata Kowalczyk-Zając1,A,D,E, Tomasz Pytrus2,A,D,E

1 Department of Conservative Dentistry and Pedodontics, Wroclaw Medical University, Poland

2 2nd Department of Pediatrics, Gastroenterology and Nutrition, Wroclaw Medical University, Poland

Abstract

Cystic fibrosis is a genetic disorder in which the mutation of the Cystis Fibrosis Transmembrane Conductance Regulator (CFTR) gene that codes the protein forming a chloride channel of epithelial cells results in its distorted functioning. The manifestations of the disorder are mainly observed in the respiratory and digestive system. Accumulation of sticky and thick mucus is the dominant clinical symptom; it leads to chronic infections and gradual tissue destruction. Although cystic fibrosis remains incurable, it is currently feasible to extend patients’ life expectancy thanks to modern therapy possibilities. As cystic fibrosis is no longer the domain of pediatricians, health care to CF patients needs to be provided by doctors of various specializations. The multidisciplinary team of doctors should include a dentist aware of specific prevention and treatment needs of this group of patients. It results from the fact that in the course of cystic fibrosis it is possible to observe a variety of changes in the oral cavity environment. The study presents dental issues observed in CF patients and reported in literature. Particular attention was paid to dental caries, mineralization disorders of hard dental tissues, gingivitis and the change in the content and properties of saliva; moreover, prevention and treatment options regarding oral cavity health is this group of patients were taken into consideration.

Key words

cystic fibrosis, gastrointestinal disorders, oral disease, genetic markers

References (38)

  1. Walkowiak J, Pogorzelski A, Sands D, et al. Zasady rozpoznawania i leczenia mukowiscydozy: Zalecenia Polskiego Towarzystwa Mukowiscydozy 2009 Poznań – Warszawa – Rzeszów. Standardy Medyczne. 2009;6:352–378.
  2. Cutting RG. Cystic fibrosis genetics: From molecular understanding to clinical application. Nat Rev Genet. 2015;16(1):45–56.
  3. Peker S, Kargul B, Tanboga I, et al. Oral health and related factors in a group of children with cystic fibrosis in Istanbul, Turkey. Niger J Clin Pract. 2015;18(1):56–60.
  4. Witt M, Majka L. Cystic fibrosis-a disease well studied but still mysterious. Alerg Astma Immunol. 1997;2(3):157–161.
  5. Kloch M, Stanisławska J. Cystic Fibrosis. CEJSH. 2014;2:11–17.
  6. Catalán MA, Nakamoto T, Gonzalez-Begne M, et al. Cftr and ENaC ion channels mediate NaCl absorption in the mouse submandibular gland. J Physiol. 2010;588(4):713–724.
  7. Catalán MA, Scott-Anne K, Klein MI, et al. Elevated incidence of dental caries in a mouse model of cystic fibrosis. PLoS One. 2011;31;6(1):e16549.
  8. Rosenstein BJ, Cutting GR. The diagnosis of cystic fibrosis: A consensus statement. Cystic fibrosis Foundation Consensus Panel. J Pediatr. 1998;132(4):589–595.
  9. Dziekiewicz MA, Banaszkiewicz A, Urzykowska A, et al. Gastroesophageal reflux disease in children with cystic fibrosis. Adv Exp Med Biol. 2015;19 [Epub ahead of print].
  10. Neglia JP, FitzSimmons SC, Maisonneuve P, et al. The risk of cancer among patients with cystic fibrosis. Cystic Fibrosis and Cancer Study Group. N Engl J Med. 1995;332(8):494–499.
  11. Olejniczak M, Wierchoła B, Emerich-Poplatek K, Adamowicz-Klepalska B. Oral cavity ecology with respect to dental status and dental treatment needs in examined population of patients suffering from cystic fibrosis. Dent Med Probl. 2003;40(2):337–347.
  12. Narang A, Maguire A, Nunn JH, Bush A. Oral health and related factors in cystic fibrosis and other chronic respiratory disorders. Arch Dis Child. 2003;88(8):702–707.
  13. Moursi AM, Fernandez JB, Daronch M, Zee L, Jones CL. Nutrition and oral health considerations in children with special health care needs: Implications for oral health care providers. Pediatr Dent. 2010;32(4):333–342.
  14. Maguire A, Rugg-Gunn AJ, Butler TJ. Dental health of children taking antimicrobial and non-antimicrobial liquid oral medication long-term. Caries Res. 1996;30(1):16–21.
  15. Dąbrowska E, Błahuszewska K, Minarowska A, Kaczmarski M, Niedźwiecka-Andrzejewicz I, Stokowska W. Assessment of dental status and oral hygiene in the study population of cystic fibrosis patients in the Podlasie province. Adv Med Sci. 2006;51(Suppl 1):100–103.
  16. Kinirons MJ. Dental health of patients suffering from cystic fibrosis in Northern Ireland. Community Dent Health. 1989;6(2):113–120.
  17. Kinirons MJ. Increased salivary buffering in association with a low caries experience in children suffering from cystic fibrosis. J Dent Res. 1983;62(7):815–817.
  18. Peker S, Mete S, Gokdemir Y, Karadag B, Kargul B. Related factors of dental caries and molar incisor hypomineralisation in a group of children with cystic fibrosis. Eur Arch Paediatr Dent. 2014;15(4):275–280.
  19. Chi DL. Dental caries prevalence in children and adolescents with cystic fibrosis: A qualitative systematic review and recommendations for future research. Int J Paediatr Dent. 2013;23(5):376–386.
  20. Ferrazzano GF, Orlando S, Sangianantoni G, Cantile T, Ingenito A. Dental and periodontal health status in children affected by cystic fibrosis in a southern Italian region. Eur J Paediatr Dent. 2009;10(2):65–68.
  21. Aps JK, Van Maele GO, Martens LC. Oral hygiene habits and oral health in cystic fibrosis. Eur J Paediatr Dent. 2002;3(4):181–187.
  22. Aps JK, Martens LC. Oral health risks in patients with cystic fibrosis. Rev Belge Med Dent. 2004;59(2):114–120.
  23. Primosch RE. Tetracycline discoloration, enamel defects, and dental caries in patients with cystic fibrosis. Oral Surg Oral Med Oral Pathol. 1980;50(4):301–308.
  24. Kinirons MJ. The effect of antibiotic therapy on the oral health of cystic fibrosis children. Int J Paediatr Dent. 1992;2(3):139–143.
  25. Sorscher EJ, Breslow JL. Cystic fibrosis: A disorder of calcium-stimulated secretion and transepithelial sodium transport? Lancet. 1982;1(8268):368–370.
  26. Cameron AC. Handbook of Pediatric Dentistry. 3rd ed. Wroclaw: Elsevier Urban&Partner; 2008:248–257, 458–459.
  27. Bronckers AL, Lyaruu DM, Guo J, et al. Composition of mineralizing incisor enamel in cystic fibrosis transmembrane conductance regulator-deficient mice. Eur J Oral Sci. 2015;123(1):9–16.
  28. Chang EH, Lacruz RS, Bromage TG, et al. Enamel pathology resulting from loss of function in the cystic fibrosis transmembrane conductance regulator in a porcine animal model. Cells Tissues Organs. 2011;194(2–4):249–254.
  29. Tuggle KL, Birket SE, Cui X, et al. Characterization of defects in ion transport and tissue development in cystic fibrosis transmembrane conductance regulator (CFTR)-knockout rats. PLoS One. 2014;7;9(3):e91253.
  30. Wright JT1, Kiefer CL, Hall KI, Grubb BR. Abnormal enamel development in a cystic fibrosis transgenic mouse model. J Dent Res. 1996;75(4):966–973.
  31. Ferrazzano GF, Sangianantoni G, Cantile T, Amato I, Orlando S, Ingenito A. Dental enamel defects in Italian children with cystic fibrosis: An observational study. Community Dent Health. 2012;29(1):106–109.
  32. Azevedo TD, Feijó GC, Bezerra AC. Presence of developmental defects on enamel in cystic fibrosis patients. J Dent Child (Chic). 2006;73(3):159–163.
  33. Olejniczak M, Wierchoła B, Emerich-Poplatek K, Adamowicz-Klepalska B. Periodontal Status and Periodontal Treatment Needs among Patients Suffering from Cystic Fibrosis. Dent Med Probl. 2004;41(3)461–467.
  34. Gonçalves AC, Marson FA, Mendonça RM, et al. Saliva as a potential tool for cystic fibrosis diagnosis. Diagn Pathol. 2013;8:46.
  35. Droebner K, Sandner P. Modification of the salivary secretion assay in F508del mice – The murine equivalent of the human sweat test. J Cyst Fibros. 2013;12(6):630–637.
  36. da Silva Modesto KB, de Godói Simões JB, de Souza AF, et al. Salivary flow rate and biochemical composition analysis in stimulated whole saliva of children with cystic fibrosis. Arch Oral Biol. 2015; 60(11):1650–1654.
  37. Livnat G, Bentur L, Kuzminsky E, Nagler RM. Salivary profile and oxidative stress in children and adolescents with cystic fibrosis. J Oral Pathol Med. 2010;39(1):16–21.
  38. Minarowski Ł, Sands D, Minarowska A, et al. Thiocyanate concentration in saliva of cystic fibrosis patients. Folia Histochem Cytobiol. 2008;46(2):245–246.
© Wroclaw Medical University