Advances in Clinical and Experimental Medicine

Title abbreviation: Adv Clin Exp Med
JCR Impact Factor (IF) – 2.1 (5-Year IF – 2.0)
Journal Citation Indicator (JCI) (2023) – 0.4
Scopus CiteScore – 3.7 (CiteScore Tracker 3.3)
Index Copernicus  – 161.11; MNiSW – 70 pts

ISSN 1899–5276 (print)
ISSN 2451-2680 (online)
Periodicity – monthly

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Advances in Clinical and Experimental Medicine

2016, vol. 25, nr 1, January-February, p. 129–133

doi: 10.17219/acem/32629

Publication type: original article

Language: English

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Evaluation of Soft Tissue Reaction to Corundum Ceramic Implants Infiltrated with Colloidal Silver

Witold Wnukiewicz1,A,B,C,D,F, Roman Rutowski2,A,C, Beata Zboromirska-Wnukiewicz3,A,B,C, Paweł Reichert1,C,E, Jerzy Gosk1,C,D,E,F

1 Department of Traumatology, Clinic of Traumatology and Hand Surgery, Wroclaw Medical University, Poland

2 Department of Sport Medicine, The University School of Physical Education, Wrocław, Poland

3 Department of Ceramics and Bioplastics, Institute of Electrical Engineering, Wrocław, Poland


Background. Corundum ceramic is a biomaterial used as a bone graft substitute. Silver is a well known antiseptic substance with many practical, clinical applications.
Objectives. The aim of this study was to estimate soft tissue (in vivo) reaction to a new kind of ceramic implants. In our experiment, we examined the soft tissue reaction after implantation of corundum ceramic infiltrated with colloidal silver in the back muscles of 18 Wistar rats. The use of colloidal silver as a coating for the implant was designed to protect it against colonization by bacteria and the formation of bacterial biofilm.
Material and Methods. In our study, based on the experimental method, we performed implantation operations on 18 Wistar rats. We implanted 18 modified ceramic implants and, as a control group, 18 unmodified implants. As a follow up, we observed the animals operated upon, and did postoperative, autopsy and histopathological examinations 14, 30, 90 and 180 days after implantation.
Results. We didn’t observe any pathological reactions and significant differences between the soft tissue reaction to the modified implants and the control group.
Conclusion. Lack of pathological reaction to the modified implants in the living organism is the proof of their biocompatibility. This is, of course, the first step on the long path to introduce a new kind of biocompatible ceramic implant with antiseptic cottage. Our experiment has an only introductory character and we plan to perform other, more specific, tests of this new kind of implant.

Key words

biomaterials, corundum ceramic, colloidal silver, implants

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