Advances in Clinical and Experimental Medicine

Title abbreviation: Adv Clin Exp Med
JCR Impact Factor (IF) – 1.736
5-Year Impact Factor – 2.135
Index Copernicus  – 168.52
MEiN – 70 pts

ISSN 1899–5276 (print)
ISSN 2451-2680 (online)
Periodicity – monthly

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Advances in Clinical and Experimental Medicine

2015, vol. 24, nr 1, January-February, p. 161–165

doi: 10.17219/acem/38144

Publication type: review article

Language: English

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Neuroprotective Effect of Resveratrol Against Glutamate-Induced Excitotoxicity

*Li-Nan Zhang1,2,A, *Liang Hao3,B, Hai-Yan Wang4,D, Hong-Ning Su5,C, Yong-Jun Sun1,2,C, Xiao-Yue Yang1,C, Bin Che1,B, Jiao Xue1,B, Zi Bin Gao1,2,F

1 Pharmacy Department, Hebei University of Science and Technology, Shijiazhuang, Hebei, China

2 State Key Laboratory Breeding Base, Hebei Province Key Laboratory of Molecular Chemistry for Drugs, Shijiazhuang, Hebei, China

3 Department of Neurosurgery, Third Hospital of Shijiazhuang, Shijiazhuang, Hebei, China

4 Pharmaceutical Preparation Section, Third Hospital of Shijiazhuang, Shijiazhuang, Hebei, China

5 Pharmaceutical Preparation Section, Fourth Hospital of Shijiazhuang, Shijiazhuang, Hebei, China


As the major neurotransmitter in the mammalian central nervous system (CNS), excessive extracellular glutamate (Glu) can activate the Glu receptors and neuronal calcium (Ca2+) overload, then produce neurotoxicity, which is a common pathway for neuronal injury or death, and is associated with acute and chronic neurodegenerative diseases. Therefore, it has been a therapeutic strategy to investigate neuroprotective effects against Glu-induced neurotoxicity for treating both acute and chronic forms of neurodegeneration. Resveratrol (Res), as a naturally occurring polyphenol mainly found in grapes and red wine, has shown a neuroprotective effect in a variety of experimental models for neurodegenerative diseases in vitro and in vivo. This review will focus on the neuroprotective effect of Res against Glu-induced excitotoxicity in neurodegenerative diseases by blocking different Glu receptors and Ca2+ ion channels.

Key words

resveratrol, glutamate, excitotoxicity, neuroprotective effect.

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