Advances in Clinical and Experimental Medicine
2015, vol. 24, nr 1, January-February, p. 161–165
doi: 10.17219/acem/38144
Publication type: review
Language: English
Download citation:
Neuroprotective Effect of Resveratrol Against Glutamate-Induced Excitotoxicity
1 Pharmacy Department, Hebei University of Science and Technology, Shijiazhuang, Hebei, China
2 State Key Laboratory Breeding Base, Hebei Province Key Laboratory of Molecular Chemistry for Drugs, Shijiazhuang, Hebei, China
3 Department of Neurosurgery, Third Hospital of Shijiazhuang, Shijiazhuang, Hebei, China
4 Pharmaceutical Preparation Section, Third Hospital of Shijiazhuang, Shijiazhuang, Hebei, China
5 Pharmaceutical Preparation Section, Fourth Hospital of Shijiazhuang, Shijiazhuang, Hebei, China
Abstract
As the major neurotransmitter in the mammalian central nervous system (CNS), excessive extracellular glutamate (Glu) can activate the Glu receptors and neuronal calcium (Ca2+) overload, then produce neurotoxicity, which is a common pathway for neuronal injury or death, and is associated with acute and chronic neurodegenerative diseases. Therefore, it has been a therapeutic strategy to investigate neuroprotective effects against Glu-induced neurotoxicity for treating both acute and chronic forms of neurodegeneration. Resveratrol (Res), as a naturally occurring polyphenol mainly found in grapes and red wine, has shown a neuroprotective effect in a variety of experimental models for neurodegenerative diseases in vitro and in vivo. This review will focus on the neuroprotective effect of Res against Glu-induced excitotoxicity in neurodegenerative diseases by blocking different Glu receptors and Ca2+ ion channels.
Key words
resveratrol, glutamate, excitotoxicity, neuroprotective effect.
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