Advances in Clinical and Experimental Medicine
2015, vol. 24, nr 1, January-February, p. 161–165
Publication type: review article
Neuroprotective Effect of Resveratrol Against Glutamate-Induced Excitotoxicity
1 Pharmacy Department, Hebei University of Science and Technology, Shijiazhuang, Hebei, China
2 State Key Laboratory Breeding Base, Hebei Province Key Laboratory of Molecular Chemistry for Drugs, Shijiazhuang, Hebei, China
3 Department of Neurosurgery, Third Hospital of Shijiazhuang, Shijiazhuang, Hebei, China
4 Pharmaceutical Preparation Section, Third Hospital of Shijiazhuang, Shijiazhuang, Hebei, China
5 Pharmaceutical Preparation Section, Fourth Hospital of Shijiazhuang, Shijiazhuang, Hebei, China
As the major neurotransmitter in the mammalian central nervous system (CNS), excessive extracellular glutamate (Glu) can activate the Glu receptors and neuronal calcium (Ca2+) overload, then produce neurotoxicity, which is a common pathway for neuronal injury or death, and is associated with acute and chronic neurodegenerative diseases. Therefore, it has been a therapeutic strategy to investigate neuroprotective effects against Glu-induced neurotoxicity for treating both acute and chronic forms of neurodegeneration. Resveratrol (Res), as a naturally occurring polyphenol mainly found in grapes and red wine, has shown a neuroprotective effect in a variety of experimental models for neurodegenerative diseases in vitro and in vivo. This review will focus on the neuroprotective effect of Res against Glu-induced excitotoxicity in neurodegenerative diseases by blocking different Glu receptors and Ca2+ ion channels.
resveratrol, glutamate, excitotoxicity, neuroprotective effect.
- Albright TD, Jessell TM, Kandel ER, Posner MI: Neural science: a century of progress and the mysteries that remain. Cell 2000, 100 Suppl, 1–55.
- Dong XX, Wang Y, Qin ZH: Molecular mechanisms of excitotoxicity and their relevance to pathogenesis of neurodegenerative diseases. Acta Pharmacol Sin 2009, 30, 379–387.
- Choi DW: Glutamate neurotoxicity and diseases of the nervous system. Neuron 1988, 1, 623–634.
- Lipton SA, Rosenberg PA: Excitatory amino acids as a final common pathway for neurologic disorders. N Engl J Med 1994, 330, 613–622.
- Coyle JT: Neurotoxic action of kainic acid. J Neurochem 1983, 41, 1–11.
- Finkbeiner S, Stevens CF: Applications of quantitative measurements for assessing glutamate neurotoxicity. Proc Natl Acad Sci USA 1988, 85, 4071–4074.
- Choi DW: Calcium-mediated neurotoxicity: relationship to specific channel types and role in ischemic damage. Trends Neurosci 1988, 11, 465–469.
- Sayin O, Arslan N, Guner G: The protective effects of resveratrol on human coronary artery endothelial cell damage induced by hydrogen peroxide in vitro. Acta Clin Croat 2012, 51, 227–235.
- Kim J, Lee HJ, Lee KW: Naturally occurring phytochemicals for the prevention of Alzheimer’s disease. J Neurochem 2010, 112, 1415–1430.
- Robb EL, Stuart JA: trans-Resveratrol as a neuroprotectant. Molecules 2010, 15, 1196–1212.
- Yanez M, Galan L, Matias-Guiu J, Vela A, Guerrero A, Garcia AG: CSF from amyotrophic lateral sclerosis patients produces glutamate independent death of rat motor brain cortical neurons: protection by resveratrol but not riluzole. Brain Res 2011, 1423, 77–86.
- Chung IM, Yeo MA, Kim SJ, Moon HI: Neuroprotective effects of resveratrol derivatives from the roots of Vitis thunbergii var. sinuate against glutamate-induced neurotoxicity in primary cultured rat cortical cells. Hum Exp Toxicol 2011, 30, 1404–1408.
- Fukui M, Choi HJ, Zhu BT: Mechanism for the protective effect of resveratrol against oxidative stress-induced neuronal death. Free Radic Biol Med 2010, 49, 800–813.
- de Almeida LM, Pineiro CC, Leite MC: Resveratrol increases glutamate uptake, glutathione content, and S 100B secretion in cortical astrocyte cultures. Cell Mol Neurobiol 2007, 27, 661–668.
- Moldzio R, Radad K, Krewenka C, Kranner B, Duvigneau JC, Rausch WD: Protective effects of resveratrol on glutamate-induced damages in murine brain cultures. J Neural Transm 2013.
- Lee JG, Yon JM, Lin C, Jung AY, Jung KY, Nam SY: Combined treatment with capsaicin and resveratrol enhances neuroprotection against glutamate-induced toxicity in mouse cerebral cortical neurons. Food Chem Toxicol 2012, 50, 3877–3885.
- Gao ZB, Chen XQ, Hu GY: Inhibition of excitatory synaptic transmission by trans-resveratrol in rat hippocampus. Brain Res 2006, 1111, 41–47.
- Zhou H, Chen Q, Kong DL, Guo J, Wang Q, Yu SY: Effect of resveratrol on gliotransmitter levels and p 38 activities in cultured astrocytes. Neurochem Res 2011, 36, 17–26.
- dos Santos AQ, Nardin P, Funchal C: Resveratrol increases glutamate uptake and glutamine synthetase activity in C 6 glioma cells. Arch Biochem Biophys 2006, 453, 161–167.
- Chang Y, Wang SJ: Inhibitory effect of glutamate release from rat cerebrocortical nerve terminals by resveratrol. Neurochem Int 2009, 54, 135–141.
- Petroni D, Tsai J, Mondal D, George W: Attenuation of low dose methylmercury and glutamate induced-cytotoxicity and tau phosphorylation by an N-methyl-D-aspartate antagonist in human neuroblastoma (SHSY 5Y) cells. Environ Toxicol 2011.
- Tanovic A, Alfaro V: [Glutamate-related excitotoxicity neuroprotection with memantine, an uncompetitive antagonist of NMDA-glutamate receptor, in Alzheimer’s disease and vascular dementia]. Rev Neurol 2006, 42, 607–616.
- Szado T, Vanderheyden V, Parys JB: Phosphorylation of inositol 1,4,5-trisphosphate receptors by protein kinase B/Akt inhibits Ca 2+ release and apoptosis. Proc Natl Acad Sci USA 2008, 105, 2427–2432.
- Wang HG, Pathan N, Ethell IM: Ca 2+-induced apoptosis through calcineurin dephosphorylation of BAD. Science 1999, 284, 339–343.
- Zeng Z, Li W, Yao Y, Chen N: Study on the mechanism of glutamate mediated neurotoxicity by cortical neuron culture technique in vitro. Hua Xi Yi Ke Da Xue Xue Bao 1999, 30, 329–330.