Advances in Clinical and Experimental Medicine

Title abbreviation: Adv Clin Exp Med
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Advances in Clinical and Experimental Medicine

2014, vol. 23, nr 5, September-October, p. 743–748

Publication type: original article

Language: English

The Influence of Physical Training on Endothelial Function in Patients with Stable Coronary Artery Disease

Małgorzata Porębska1,A,B,C,D,E,F, Walentyna Mazurek1,A,B,C,D,E,F

1 Department and Clinic of Cardiology, Wroclaw Medical University, Poland

Abstract

Background. Endothelial damage is the key factor in the pathophysiology of atherosclerosis. Regular physical activity exerts beneficial direct and indirect effects on, among others, cardiovascular system, locomotor system, lipids, carbohydrate and hormonal balance, maintenance of a proper body weight as well as immunological system.
Objectives. The aim of the study included evaluating the effect of a regular, two-month physical training on endothelial function parameters in patients with stable coronary artery disease.
Material and Methods. The study involved 61 patients after coronary angioplasty, 13 women and 48 men aged 62.8 ± 8.7 years. The control group included 21 subjects aged 63.2 ± 9.7 years, 17 of whom had hypertension which was well controlled pharmacologically. Blood for VCAM-1 and ICAM-1 was collected with the subjects remaining for 30 min in supine position, through a venous access inserted in the basilica vein. In the patients’ group the blood was collected twice, prior to and after a physical training cycle. In controls the blood was collected once.
Results. The investigated groups differ slightly but not in a statistically significant way with regard to the hemodynamic parameters BP 124.4/75.9 vs. 123.4/76.3 mm Hg, p = ns., HR 66.2 ± 6.8 vs. 68.8 ± 6.3 bpm, p = ns., left ventricular ejection fraction – EF 60.1 ± 7.6 vs. 63.7 ± 5.2 %, p < 0.05 and did not differ with regard to the incidence of hypertension or BMI value. The level of soluble ICAM-1 prior to physical training was higher in the investigated group (289.0 ± 97.1 vs. 230.2 ± 47.1 ng/mL, p < 0.01) and after the training it decreased but remained higher than in control group (252.4 ± 100.8 ng/mL, p < 0.05. vs. control group). The level of soluble VCAM-1 did not differ initially between the groups, nor did it change significantly after the training.
Conclusion. Moderately intense physical training only slightly affects the investigated parameters of the endothelial function in patients with coronary artery disease. A beneficial effect of training on endothelial function was observed as a decrease of the level of soluble ICAM-1. 8-week, moderately intense physical training is sufficient to cause a clinically significant decrease in arterial blood pressure.

Key words

endothelium function, physical training, ICAM-1, VCAM-1.

References (16)

  1. Ross R: Atherosclerosis – an Inflammatory Disease. N Engl J Med 1999, 340, 115–126.
  2. Granger D, Vowinkel T, Petnehazy T: Modulation of the Inflammatory Response in Cardiovascular Disease. Hypertension 2004, 43, 924–931.
  3. Cines DB, Pollack ES, Buck CA, Loscalzo J, Zimmerman GA, McEver RP, Pober JS, Wick TM, Konkle BA, Schwartz BS, Barnathan ES, McCrae KR, Hug BA, Schmidt AM, Stern DM: Endothelial cells in physiology and in the pathophysiology of vascular disorders. Blood 1998, 91, 3527–3561.
  4. Moncada S, Higgs A: The L-arginine-nitric oxide pathway. N Engl J Med 1993, 329, 2002–2012.
  5. Ross R: Cellular mechanisms of atherosclerosis. Atheroscler Rev 1993, 25, 195–200.
  6. Jang Y, Lincoff M, Plow EF, Topol EJ: Cell adhesion molecules in coronary artery disease. J Am Cardiol 1994, 24, 1591–1601.
  7. Smith CW: Leukocyte-endothelial cell interactions. Semin Hematol 1993, 30, Suppl 4, 45–55.
  8. Gatti JC: Exercise-based rehabilitation for coronary heart disease. Am Fam Physician 2004, 70, 485–486.
  9. Green DJ, Maiorana A, O’Driscoll G, Taylor R: Effect of exercise training on endothelium-derived nitric oxide function in humans. Physiology 2004, 561, 1–25
  10. Al-Isa AN, Thalib L, Akanji AO: Circulating markers of inflammation and endothelial dysfunction in Arab adolescent subjects: reference ranges and associations with age, gender, body mass and insulin sensitivity. Atherosclerosis 2010, 208, 543–549.
  11. Saetre T, Enoksen E, Lyberg T, Stranden E, Jørgensen JJ, Sundhagen JO, Hisdal J: Supervised exercise training reduces plasma levels of the endothelial inflammatory markers E-selectin and ICAM-I in patients with peripheral arterial disease. Angiology 2011, 62, 301–305.
  12. Ranković G, Milicić B, Savić T, Dindić B, Mancev Z, Pesić G: Effects of physical exercise on inflammatory parameters and risk for repeated acute coronary syndrome in patients with ischemic heart disease. Vojnosanit Pregl 2009, 66, 44–48.
  13. Zoppini G, Targher G, Zamboni C, Venturi C, Cacciatori V, Moghetti P, Muggeo M: Effects of moderateintensity exercise training on plasma biomarkers of inflammation and endothelial dysfunction in older patients with type 2 diabetes. Nutr Metab Cardiovasc Dis 2006, 16, 543–549.
  14. Brevetti G, De Caterina M, Martone VD, Ungaro B, Corrado F, Silvestro A, de Cristofaro T, Scopacasa F: Exercise increases soluble adhesion molecules ICAM-1 and VCAM-1 in patients with intermittent claudication. Clin Hemorheol Microcirc 2001, 24, 193–199.
  15. Laughlin MH, Bowles DK, Duncker DJ: The coronary circulation in exercise training. Am J Physiol Heart Circ Physiol 2012, 302, 10–23.
  16. Libby P, Aikawa M, Kinlay S, Selwyn A, Ganz P: Lipid lowering improves endothelial functions. Int J Cardiol 2000, 74, Suppl 1, 3–10.
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