Advances in Clinical and Experimental Medicine

Title abbreviation: Adv Clin Exp Med
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Advances in Clinical and Experimental Medicine

2014, vol. 23, nr 5, September-October, p. 735–741

Publication type: original article

Language: English

Soluble Cell Adhesion Molecules – Does Estimating sVCAM-1 and sICAM-1 Concentration Provide Additional Information About Cardiovascular Risk in Patients with Coronary Artery Disease?

Anna Hulok1,A,B,D,E,F, Krzysztof Ściborski1,A,B,D,E,F, Jakub Marczak2,3,*,C,D,E, Tomasz Bańkowski1,A,C,D,E,F, Rafał Poręba4,C,E,F, Marta Negrusz-Kawecka1,A,B,D,E,F

1 Department and Clinic of Cardiology, Wroclaw Medical University, Poland

2 Department and Clinic of Cardiac Surgery, Wroclaw Medical University, Poland

3 Department of Cardiac Surgery, Medinet Heart Center Ltd., Nowa Sol, Poland

4 Department and Clinic of Internal and Occupational Diseases and Hypertension, Wroclaw Medical University, Poland

Abstract

Objectives. Cell adhesion molecules (CAM) are thought to have a great impact on endothelium functioning. Interaction between CAM and a receptor may lead to macrophage activation and the release of multiple enzymes such as elastases and colagenases. These enzymes can, in turn, play a role in atherosclerotic plaque destabilization and initiation of acute coronary syndrome (ACS). The main aim of this study was to assess the role of sVCAM-1 and sICAM-1 in the risk stratification of ACS.
Material and Methods. 63 patients – mean age 62.7 ± 9.5 years (26 women, 37 men) – were included in the study. Patients were divided into two groups: I – patients with acute coronary syndrome (ACS) diagnosed by coronary angiography (n = 45: 15 women; 30 men); and II – patients without apparent CAD in coronary angiography (n = 18: 11 women, 7 men). In both groups, samples required for sVCAM-1 and sICAM-1 level measurements were collected before the angiography.
Results. Mean age, prevalence of arterial hypertension, diabetes mellitus and chronic kidney disease did not differ between the groups. Levels of sVCAM-1 and sICAM-1 were significantly higher in group I (group I vs. group II: 850.3 ± 337.9 vs. 675.9 ± 178.8; p = 0.02 and 737.2 ± 353.5 vs. 428.5 ± 157.3; p = 0.001 respectively). ROC analysis revealed that there is significantly higher risk of ACS above the level of 700.15 ng/mL for sVCAM-1 and 407.8 ng/mL for sICAM-1. The level of sVCAM-1 was also found to be an independent risk factor of NSTEMI, OR 1.003 (95% CI: 1.0007–1.004); p = 0.007, but not of STEMI (p > 0.05).
Conclusion. Levels of sVCAM-1 and sICAM-1 were found to be negative predictors of acute coronary syndrome. Further studies should assess the relationship between sVCAM-1 and sICAM-1 levels and the survival of patients suffering from CAD.

Key words

sVCAM-1, sICAM-1, soluble cell adhesion molecules, coronary artery disease, STEMI, NSTEMI, acute coronary syndrome, risk factor.

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