Advances in Clinical and Experimental Medicine

Title abbreviation: Adv Clin Exp Med
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Advances in Clinical and Experimental Medicine

2014, vol. 23, nr 3, May-June, p. 395–398

Publication type: original article

Language: English

Is Cetrimide-Chlorhexidine Risky for Secondary Sclerosing Cholangitis?

Cemalettin Aydin1,A,B,C,D,F, Cuneyt Kayaalp1,B,D,E, Gurel Nessar2,A,C,F, Neslihan Zengin2,C,D,E, Mujdat Balkan3,B,C,F, Bulent Unal1,A,D,E, Taner Ozgurtas3,A,C,E

1 Inonu University, Turgut Ozal Medical Center, Department of General Surgery, Malatya, Turkey

2 Turkey Yuksek Ihtisas Hospital, Department of Gastrointestinal Surgery, Ankara, Turkey

3 Gulhane Military Medicine Academy, Department of General Surgery, Ankara, Turkey

Abstract

Background. The liver is the most frequent organ for placement of hydatid cyst disease. All known protoscolicidals that are used for echinococcus degeneration have a risk of caustic secondary sclerosing cholangitis. The cetrimidechlorhexidine combination is an effective protoscolicidal agent for treatment of hydatid liver cysts.
Objectives. The aim of this experimental study was to examine this combination for potential risks of caustic secondary sclerosing cholangitis.
Material and Methods. Thirty rats were enrolled and divided into two groups. In the study group, 0.15 mL of a cetrimide (0.5%) and chlorhexidine (0.05%) combination was injected into the bile ducts for five minutes. The control group included the same amount of normal saline and waiting period. The rats were followed for 120 days and the living rats were examined for biliary injury by biochemical analysis and histopathology.
Results. No specific histopathological findings for caustic sclerosing cholangitis such as bile duct stricture or periductal fibrosis were present in any groups. Other pathological criteria demonstrating inflammation including portal inflammation, bile duct proliferation and necrosis were similar in both groups. biochemical analysis including a liver function test (aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, gamma-glutamyltranspeptidase) appeared similar to the control group.
Conclusion. A cetrimide 0.5% and chlorhexidine 0.05% combination has similar liver function results and histopathological effects to normal saline on bile ducts and it appears to be safe for bile ducts.

Key words

cetrimide, chlorhexidine, bile duct, cholangitis, echinococcus granulosus.

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