Advances in Clinical and Experimental Medicine

Title abbreviation: Adv Clin Exp Med
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ISSN 1899–5276 (print)
ISSN 2451-2680 (online)
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Advances in Clinical and Experimental Medicine

2013, vol. 22, nr 6, November-December, p. 893–898

Publication type: review article

Language: English

Topical Application of Drugs Used in Treatment of Oral Lichen Planus Lesions

Miejscowe stosowanie leków w leczeniu zmian liszaja płaskiego błony śluzowej jamy ustnej

Małgorzata Radwan-Oczko 1,

1 Department of Periodontology, Oral Pathology, Wrocław Medical University

Abstract

Oral lichen planus is a common, chronic mucosal disease associated with a cell-mediated immunological dysfunction. The clinical manifestation is different when various forms, white and red, are considered. Erosive, atrophic, ulcerative lesions require long-term treatment, because of inflammation and severe pain. Since the etiology is still unknown this symptomatic OLP lesions are not curative. The effectiveness of various modalities applied in topical OLP treatment is presented on the basis of the current literature. This treatment in most cases is palliative because of OLP recalcitrant nature. Described agents such: steroids, immunosupressants, aloe vera, hyaluronic acid, antifungal showed beneficial effects. They enhance healing, improve signs and symptoms of lesions and thus improve the quality of patients’ life. Topical treatment is recommended mainly because of minimal side-effects

Streszczenie

Liszaj płaski błony śluzowej jamy ustnej jest często występującą, przewlekłą chorobą błony śluzowej jamy ustnej związaną z dysfunkcją komórek immunokompetentnych. Obraz kliniczny zmian różni się i jest związany z występowaniem białych i czerwonych postaci liszaja. Zmiany erozyjne, atroficzne, wrzodziejące wymagają długotrwałego leczenia w związku z zapaleniem i towarzyszącym silnym bólem. Ponieważ etiologia liszaja jest nadal nieznana, te zmiany są trudne w leczeniu. Na podstawie aktualnych doniesień piśmiennictwa przedstawiono korzyści związane z miejscowym stosowaniem różnych leków w leczeniu liszaja płaskiego błony śluzowej jamy ustnej. Leczenie to jest w większości przypadków objawowe, spowodowane nawrotowym charakterem zmian. Opisano zastosowanie leków wykazujących działanie korzystne: steroidy, leki immunosupresyjne, wyciągi aloesu, kwas hialuronowy, leki przeciwgrzybiczne. Ułatwiają one gojenie zmian, zmniejszają objawy zapalenia i objawy kliniczne, co wpływa na poprawę jakości życia pacjentów. Leczenie miejscowe zmian liszaja płaskiego jest polecane ze względu na występowanie niewielkich skutków ubocznych tej terapii

Key words

oral lichen planus, topical treatment, drugs.

Słowa kluczowe

liszaj płaski, leczenie miejscowe, leki.

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