Advances in Clinical and Experimental Medicine

Title abbreviation: Adv Clin Exp Med
JCR Impact Factor (IF) – 2.1 (5-Year IF – 2.0)
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ISSN 1899–5276 (print)
ISSN 2451-2680 (online)
Periodicity – monthly

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Advances in Clinical and Experimental Medicine

2013, vol. 22, nr 2, March-April, p. 177–183

Publication type: original article

Language: English

The Formulation of Flurbiprofen Loaded Microspheres Using Hydroxypropylmethycellulose and Ethylcellulose

Opracowanie mikrosfer wypełnionych flurbiprofenem za pomocą hydroksypropylmetycelulozy i etylocelulozy

Muhammad K. Shahzad1,A, Muhammad Ubaid1,B, Moosa Raza1,C,D, Ghulam Murtaza2,E,F

1 Faculty of Pharmacy, Bahauddin Zakariya University, Multan, Pakistan

2 Department of Pharmaceutical Sciences, COMSATS Institute of Information Technology, Abbottabad, Pakistan

Abstract

Objectives. The aim of the present work was to formulate flurbiprofen (FLB) loaded microspheres of hydroxypropylmethycellulose and ethylcellulose polymers to study the effect of different proportions of the polymer mixture on the release behavior of the drug.
Material and Methods. A series of microspheres were prepared using tween-80 as a surfactant. The prepared microspheres were evaluated for entrapment efficiency (%) and percentage recovery. Drug release was performed in USP phosphate buffers of pH 1.2 and 6.8. Drug release data were plotted in various kinetic models, including zero-order, first-order, Higuchi and Korsmeyer-Peppas models to investigate the optimum composition suitable for sustained drug delivery.
Results. A significant difference in drug release kinetics was observed by varying the composition of hydroxypropylmethycellulose/ethylcellulose. As the ratio of EC/HPMC was increased, the release rate of flurbiprofen decreased.
Conclusion. This study demonstrated the potential of polymer combinations in the formulation of microspheres for water-insoluble drugs utilizing HPMC and EC as release retardant materials, using a simple solvent evaporation microencapsulation technique. It was observed that various physico-chemical properties of the microspheres varied according to the change in polymer concentrations used in the formulations.

Streszczenie

Cel pracy. Opracowanie mikrosfer wypełnionych flurbiprofenem (FLB) za pomocą polimerów hydroksypropylmetycelulozy i etylocelulozy w celu zbadania wpływu różnych proporcji mieszaniny polimerów na uwalnianie leku.
Materiał i metody. Wytworzono zestaw mikrosfer z użyciem tween-80 jako środka powierzchniowo czynnego. Przygotowane mikrosfery oceniono pod względem wydajności uwięzienia (%) i odsetka odzyskania. Uwalnianie leku prowadzono w buforach fosforanowych o USP pH 1,2 i 6,8. Dane uwalniania leku wykreślono w różnych modelach kinetycznych, w tym rzędu zerowego, pierwszego rzędu, modelach Higuchi i Korsmeyer-Peppas badających optymalną kompozycję odpowiednią do przedłużonego uwalniania leku.
Wyniki. Zaobserwowano znaczącą różnicę kinetyki uwalniania leku w zależności od proporcji hydroksypropylmetycelulozy i etylocelulozy. Im większy stosunek EC / HPMC, tym mniejsza szybkość uwalniania flurbiprofenu.
Wnioski. Badanie to wykazało możliwości kombinacji polimerów w preparacie zawierającym mikrosfery jako nośnik leków nierozpuszczalnych w wodzie z wykorzystaniem HPMC EC jako materiałów opóźniających uwalnianie, za pomocą prostego odparowania rozpuszczalnika techniką mikrokapsułkowania. Stwierdzono, że właściwości fizykochemiczne mikrosfer zależą od zmian w stężeniu polimeru stosowanego w preparatach.

Key words

flurbiprofen, microspheres, HPMC, ethylcellulose.

Słowa kluczowe

flurbiprofen, mikrosfery, HPMC, etyloceluloza.

References (21)

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