Advances in Clinical and Experimental Medicine

Title abbreviation: Adv Clin Exp Med
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Advances in Clinical and Experimental Medicine

2013, vol. 22, nr 1, January-February, p. 119–124

Publication type: review article

Language: English

Osteoporosis: Genetic Determinants and Relationship with Cardiovascular Disease

Osteoporoza – uwarunkowania genetyczne i związek z chorobą sercowo-naczyniową

Małgorzata Sobieszczańska1,A,E,F, Jakub Jonkisz2,D, Mateusz Tabin1,D, Krystyna Laszki-Szcząchor1,B,E

1 Department of Pathophysiology, Wroclaw Medical University, Wroclaw, Poland

2 Department of Trauma-Orthopedic Surgery, Hospital of the Ministry of the Interior, Wroclaw, Poland

Abstract

Osteoporosis has become one of the major public health problems, affecting about two hundred million people worldwide, including one third of all postmenopausal women. The paper presents a review of the current literature concerning the pathophysiology and the most common genetic and environmental determinants that account for the individual predisposition to age-related osteoporosis. Particular emphasis is placed on the specific linkage between the causative factors of osteoporosis and atherosclerotic cardiovascular disease.

Streszczenie

Osteoporoza stała się jednym z głównym problemów zdrowotnych, dotykając około 200 milionów ludzi na świecie, w tym jedną trzecią kobiet w okresie pomenopauzalnym. Praca przedstawia przegląd aktualnego piśmiennictwa dotyczącego patofizjologii osteoporozy oraz najczęstszych uwarunkowań genetycznych i środowiskowych, które odpowiadają za osobnicze predyspozycje do ujawnienia się objawów osteoporozy związanej z wiekiem. W artykule szczególną uwagę zwrócono na występowanie związku przyczynowo-skutkowego między czynnikami wywołującymi osteoporozę i miażdżycową chorobę sercowo-naczyniową.

Key words

osteoporosis, candidate genes, cardiovascular disease.

Słowa kluczowe

osteoporoza, geny kandydaci, choroba sercowo-naczyniowa

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