Advances in Clinical and Experimental Medicine

Title abbreviation: Adv Clin Exp Med
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Advances in Clinical and Experimental Medicine

2012, vol. 21, nr 4, July-August, p. 469–475

Publication type: original article

Language: English

Can We Predict Urinary Stone Composition Based on an Analysis of Microelement Concentration in the Hair and Urine?

Czy można przewidzieć skład kamieni moczowych na podstawie analizy zawartości mikroelementów we włosach i w moczu?

Marcin Słojewski1,2,, Krzysztof Safranow3,, Katarzyna Jakubowska3,, Maria Olszewska3,, Andrzej Pawlik4,, Zygmunt Juzyszyn4,, Marek Droździk4,, Dariusz Chlubek3,, Peter Hammerer2,, Andrzej Sikorski1,

1 Department of Urology and Urological Oncology, Pomeranian Medical University, Szczecin, Poland

2 Urologische Klinik, Braunschweig, Germany

3 Department of Biochemistry and Medical Chemistry, Pomeranian Medical University, Szczecin, Poland

4 Department of Pharmacokinetics and Therapeutic Drug Monitoring, Pomeranian Medical University, Szczecin, Poland

Abstract

Background. In recent years the role of trace elements in lithogenesis has received steadily increasing attention.
Objectives. This study was aimed to attempt to find the correlations between the chemical content of the stones and the concentration of chosen elements in the urine and hair of stone formers.
Material and Methods. The proposal for the study was approved by the local ethics committee. Specimens were taken from 219 consecutive stone-formers. The content of the stone was evaluated using atomic absorption spectrometry, spectrophotometry, and colorimetric methods. An analysis of 29 elements in hair and 21 elements in urine was performed using inductively coupled plasma-atomic emission spectrometry.
Results. Only a few correlations between the composition of stones and the distribution of elements in urine and in hair were found. All were considered incidental.
Conclusion. The data obtained did not allow for the creation of a proper and practical algorithm to predict stone chemical composition based on hair and urine analysis.

Streszczenie

Wprowadzenie. W ostatnich latach obserwuje się rosnące naukowe zainteresowanie rolą mikroelementów w procesie tworzenia kamieni moczowych.
Cel pracy. Niniejsze badanie zostało podjęte w celu oceny potencjalnej korelacji między składem chemicznym kamieni a zawartością wybranych pierwiastków w moczu i we włosach chorych na kamicę dróg moczowych.
Materiał i metody. Projekt badania został zaakceptowany przez lokalny komitet etyczny. Próbki pobierano od kolejnych 219 chorych na kamicę, kwalifikowanych do leczenia zabiegowego. Skład kamieni badano z zastosowaniem metod spektrometrii absorpcji atomowej, spektrofotometrii i kolorymetrii. Analiza zawartości 29 pierwiastków we włosach i 21 w moczu została wykonana z użyciem spektrometru emisji atomowej z plazmą wzbudzoną indukcyjnie.
Wyniki. Wśród badanych zależności stwierdzono jedynie pojedyncze, uznane za incydentalne, korelacje między składem kamieni a zawartością pierwiastków w badanych materiałach biologicznych.
Wnioski. Uzyskane dane nie pozwalają na stworzenie odpowiedniego, praktycznego algorytmu, na podstawie którego można byłoby przewidzieć lub odtworzyć skład chemiczny kamieni moczowych.

Key words

urinary stone, urine, hair, analysis, trace elements

Słowa kluczowe

kamienie moczowe, mocz, włosy, analiza, pierwiastki śladowe

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