Advances in Clinical and Experimental Medicine

Title abbreviation: Adv Clin Exp Med
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Advances in Clinical and Experimental Medicine

2011, vol. 20, nr 4, July-August, p. 521–525

Publication type: review article

Language: English

SAPHO Syndrome as a Possible Cause of Masticatory System Anomalies – a Review of the Literature

Zespół SAPHO jako możliwa przyczyna zaburzeń układu ruchowego narządu żucia – przegląd piśmiennictwa

Mieszko Więckiewicz1,, Anna Paradowska2,, Beata Kawala3,, Włodzimierz Więckiewicz4,

1 Division of Dental Materials, Faculty of Dentistry, Wroclaw Medical University, Poland

2 Division of Dentofacial Anomalies, Department of Maxillofacial Orthopedics and Orthodontics, Faculty of Dentistry, Wroclaw Medical University, Poland

3 Department of Maxillofacial Orthopedics and Orthodontics, Faculty of Dentistry, Wroclaw Medical University, Poland

4 Division of Implantoprosthetics and Functional Disturbances of the Stomatognathic System, Faculty of Dentistry, Wroclaw Medical University, Poland

Abstract

SAPHO is a rare syndrome of unknown – probably mutlifactorial – etiology, affecting the joints, bones and skin. The name is an acronym from synovitis, acne, pustulosis, hyperostosis and osteitis. SAPHO occurs predominantly in young females. Bone defects are the most prevalent feature of the syndrome. The mandible is affected in about 10% of the cases and there are typical osteitic and sclerotic lesions. Limitation of motion in the temporomandibular joint, swelling and pain are the most common symptoms of TMJ involvement. Complete ankylosis is a rare condition. Anti-inflammatory non-steroid drugs, antibiotics and (in severe cases) tumor necrosis factor inhibitors are the most commonly used medications. In patients with ankylosis of the temporomandibular joint, follow-up observations indicate that surgical reconstruction of the joint seems to be the best solution.

Streszczenie

SAPHO jest rzadką chorobą stawów, kości i skóry o nieznanej, prawdopodobnie wieloczynnikowej etiologii. Nazwa zespołu to akronim wzięty od słów synovitis, acne, pustulosis, hyperostosis i osteitis (zapalenie błony maziowej, trądzik, łuszczyca, hiperostoza, osteoza). SAPHO pojawia się częściej u młodych kobiet. Najczęściej występującą cechą zespołu są ubytki kości. Żuchwa jest objęta procesem chorobowym u ok. 10% chorych i występują w niej typowe zmiany sklerotyczne i zapalne kości. Ograniczenie ruchów w stawie skroniowo-żuchwowym (s.s.ż.), obrzęk i ból są najczęściej występującymi objawami zajęcia s.s.ż. Całkowita ankyloza jest rzadkim zjawiskiem. Niesteroidowe leki przeciwzapalne, antybiotyki i antagoniści czynnika martwicy nowotworów TNF są najczęściej stosowanymi lekami. U pacjentów z ankylozą w obrębie s.s.ż., chirurgiczna rekonstrukcja stawu wydaje się najlepszym postępowaniem terapeutycznym. Badania kontrolne wskazują, że jest to dobra metoda leczenia.

Key words

SAPHO, TMJ disorders, ankylosis

Słowa kluczowe

SAPHO, zaburzenia stawu skroniowo-żuchwowego, ankyloza

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