Advances in Clinical and Experimental Medicine

Title abbreviation: Adv Clin Exp Med
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Advances in Clinical and Experimental Medicine

2011, vol. 20, nr 2, March-April, p. 211–215

Publication type: review article

Language: English

Swine as a Model of Experimental Atherosclerosis

Świnia jako eksperymentalny model do badań arteriosklerozy

Robert Pasławski1,, Urszula Pasławska2,, Andrzej Szuba1,, Józef Nicpoń2,

1 Department and Clinic of Internal and Occupational Diseases and Hypertension, Wroclaw Medical University, Wrocław, Poland

2 Department of Internal Medicine and Clinic of Diseases of Horses, Dogs and Cats, Wrocław University of Environmental and Life Sciences, Wrocław, Poland

Abstract

In Western countries, lifestyle changes in the past century are considered to be a major factor in obesity and related diseases such as atherosclerosis and diabetes. To gain a better understanding of the relationship between disorders of lipid metabolism and atherogenesis, many animal species have been tested. The most commonly used are laboratory animals such as mice, rats, rabbits, guinea pigs and pigeons. However, the pig is a considered a very good model of human atherosclerosis, because it is similar to humans in terms of body size and other physiological features, including its tendency to overeat. Even though there is no perfect animal model that completely replicates human atherosclerosis, the pig seems to be a promising subject for exploring the etiopathogenesis of atherosclerosis.

Streszczenie

Zmiany stylu życia, jakie nastąpiły w ostatnim wieku w państwach kultury zachodniej uważa się za najważniejszy czynnik odpowiedzialny za otyłość i choroby z nią związane, takie jak arterioskleroza i cukrzyca. Aby lepiej zrozumieć związki między zaburzeniami lipidowymi a rozwojem miażdżycy, wykonywano eksperymenty na wielu gatunkach zwierząt. Najczęściej wykorzystywano zwierzęta laboratoryjne, np. myszy, szczury, króliki, świnki morskie i gołębie. Za bardzo dobry jest uważany model świński, ponieważ dorosłe świnie mają podobną do ludzi masę ciała, budowę anatomiczną i właściwości fizjologiczne, np. skłonność do przejadania się. Nie istnieje idealny model zwierzęcy, który wiernie imitowałby rozwój choroby u człowieka, ale wydaje się, że model świński jest najbardziej obiecujący w badaniach dotyczących etiopatogenezy zmian miażdżycowych.

Key words

swine model, experimental atherosclerosis

Słowa kluczowe

model świński, eksperymentalna arterioskleroza

References (28)

  1. Glass CK, Witztum JL: Atherosclerosis. The road ahead. Cell 2001, 104, 503–516.
  2. Libby P: Inflammation in atherosclerosis. Nature 2002, 420, 868–874.
  3. Hansson GK: Inflammation, atherosclerosis, and coronary artery disease. N Engl J Med 2005, 352, 1685–1695.
  4. Falk E: Patogenesis of atherosclerosis. J Am Coll Cardiol 2006, 47, C7–12.
  5. Cos E, Ramjiganesh T, Roy S, Yoganathan S, Nicolosi RJ, Fernandez ML: Soluble fiber and soybean protein reduce atherosclerotic leasions in guinea pigs. sex and hormonal status determine lesion extension. Lipids 2001, 11, 1209–1216.
  6. Yanni AE: The laboratory rabbit: an animal model of atherosclerosis research. Lab Anim 2004, 38, 246–256.
  7. Moghadasian MH, Frohlich JJ, McManus BM: Advances in experimental dyslipidemia and atherosclerosis. Lab Invest 2001, 81, 1173–1183.
  8. Bergen WG, Mersmann HJ: Comparative aspects of lipid metabolism: impact on contemporary research and use of animal models. J Nutr 2005, 135, 2499–2502.
  9. Royo T, Alfón J, Berrozpe M, Badimon L: Effect of gemfibrozil on peripheral atherosclerosis and platelet activation in a pig model of hyperlipidemia. Eur J Clin Invest. 2000, 30(10), 843–852.
  10. Stender S, Zilversmit DB: In vivo influx, tissue estrification and hydrolisis of free and estrified plasma cholesterol in the cholesterol-fed rabbit. Biochim Biophys Acta 1981, 663, 674–679.
  11. Naghavi M, Libby P, Falk E, Casscells SW, Litovsky S, Rumberger J, Badimon JJ, Stefanadis C, Moreno P, Pasterkamp G, Fayad Z, Stone PH, Waxman S, Raggi P, Madjid M, Zarrabi A, Burke A, Yuan C, Fitzgerald PJ, Siscovick DS, de Korte CL, Aikawa M, Airaksinen KE, Assmann G, Becker CR, Chesebro JH, Farb A, Galis ZS, Jackson C, Jang IK, Koenig W, Lodder RA, March K, Demirovic J, Navab M, Priori SG, Rekhter MD, Bahr R, Grundy SM, Mehran R, Colombo A, Boerwinkle E, Ballantyne C, Insull W Jr, Schwartz RS
  12. Smochowiec L, Kadłubowska D, Wójcicki J, Dominiczak K: Experimental atherosclerosis model in domestic pigs. Pol J Pharmacol Pharm 1981, 33, 401–406.
  13. Reitman JS, Mahley RW, Fly DL: Yucatan miniature swine as a model of diet-induced atherosclerosis. Atherosclerosis 1982, 43, 119–132.
  14. Fuster V, Fass DN, Kaye MP, Josa M, Zinsmeister AR, Bowie EJW: Arteriosclerosis in normal and von Willebrand pigs. Long-term prospective study and aortic transplantation study. Circ Res 1982, 51, 587–593.
  15. Kim DN, Ho H-T, Lawrence DA, Schmee J, Thomas WA: Modification of lipoprotein patterns and retardation of atherogenesis by a fisch oil supplement to a hyperlipidemic diet for swine. Atherosclerosis 1989, 76, 35–54.
  16. Kobari Y, Koto M., Tanigawa M: Regression of diet-induced atherosclerosis in Goettingen miniature swine. Lab Anim 1991, 25, 110–116.
  17. Jacobsson L: Experimental hyperlipidemia and atherosclerosis in mini-pigs; influence of certain drugs. Scand J Lab Anim Sci 1998, 25, Suppl 1, 85–91.
  18. Holvoet P, Theilmeier G, Shivalkar B, Flameng W, Collen D: LDL Hypercholesterolemia is Associated with Accumulation of Oxidized LDL, Atherosclerotic Plaque Growth, and Compensatory Vessel Enlargement in Coronary Arteries of Miniature Pigs. Arterioscler Thromb Vasc Biol 1998, 18, 415–422.
  19. Johnson LL, Schofield L, Donahay T, Narula N: 99mTc-Annexin V imaging for in vivo detection of atherosclerotic lesions in porcine coronary arteries. J Nucl Med 2005, 46, 1186–1193.
  20. Artinger S, Deiner C, Loddenkemper C, Schwimmbeck PL, Schultheiss H, Pels K: Complex porcine model of atherosclerosis: Induction of early coronary lesions after long-term hyperlipidemia without sustained hyperglycemia. Can J Cardiol 2009, 25(4), e109–e114.
  21. Ritskes-Hoitinga P, Bollen J: Nutrition of (Göttingen) Minipigs: Facts, Assumptions and Mysteries. Basic Clin Pharmacol Toxycol 2009, 80, 5–9.
  22. Zhang SH, Reddich RL, Piedrahita JA, Maeda N: Spontaneous hypercholesreolemia and arterial lesions in mice lacking apolipoprotein. E Science 1992, 258, 468–471.
  23. Veniant MM, Zlot CH, Walzern RL, Pierotti V, Driscoll R, Dichek D, Herz J, Young SG: Lipoprotein clearance mechanisms in LDL receptor deficient “apo-B-only” and “apo-B-only” mice. J Clin Invest 1998, 102, 1559–1568.
  24. Mezdour H, Jones R, Dengeremont C, Castro G, Maeda N: Hepatic lipase deficiency increase plasma cholesterol but reduces susceptibility to atherosclerosis in apolipoprotein E-deficient mice. J Biol Chem 1997, 272, 13570– –13575.
  25. Purcell-Huynh DA, Farese RV Jr, Johanson DF, Flynn LM, Pierotti V, Newland DL, Linton MF, Sanan DA, Young SG: Transgenic mice expressing high levels of human apolipoprotein B develop severe atherosclerotic lesions in response to a high fat diet. J Clin Invest 1995, 95, 2246–2257.
  26. Marotti KR, Castle CK, Boyle TP, Lin AH, Murray RW, Melchior GW: Severe atherosclerosis in transgenic mice expressing simian cholesterylester transfer protein. Nature 1993, 364, 43–75.
  27. Harris KB, Cross GR, Pond WG, Mersmann HJ: Effect of dietary fat and cholesterol level on tissue cholesterol concentrations from growing pigs selected for high or low serum cholesterol. J Anim Sci 1993, 71, 807–810.
  28. Bentzon JF, Sorensen ChB, Kragh PM, Mikkelsen JG, Falk E, Bolund LA, Corydon TJ: Pig model for atherosclerosis. The World Intellectual Property Organization United Nations Patentscope 12.09.2008 WO/2008/106982, PCT/DK2008/050055, C12N 15/85.
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