Advances in Clinical and Experimental Medicine

Title abbreviation: Adv Clin Exp Med
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Advances in Clinical and Experimental Medicine

2009, vol. 18, nr 2, March-April, p. 183–188

Publication type: letter to editor

Language: English

Carcinoma Cell Leukemia – an Acute Leukemia−Like Picture Due to Osteoclast−Like Giant Cell Carcinoma of the Pancreas

Obraz podobny do ostrej białaczki w przebiegu raka trzustki podobnego do guza olbrzymiokomórkowego kości

Lidia Usnarska−Zubkiewicz1,, Ewa Sowińska2,, Wojciech Kielan3,, Marta Strutyńska−karpińska4 Alicja Markowska−Woyciechowska4,, Kazimierz Kuliczkowski1,

1 Department of Hematology, Blood Neoplasms and Bone Marrow Transplantation, Wroclaw Medical University, Poland

2 Lower Silesia Center of Tuberculosis and Lung Diseases, Wrocław, Poland

3 Second Department of General and Oncological Surgery, Wroclaw Medical University, Poland

4 Department of Pathological Anatomy, Wroclaw Medical University, Poland

Abstract

Carcinocythemia is a rare complication of metastatic carcinoma characterized by the presence of carcinoma cells in the peripheral blood mimicking acute leukemia. Osteoclast−like giant cell tumor is a variant of ductal adenocarcinoma of the pancreas with an aggressive course. A 33−year−old male was admitted to the Department of Hematology with anemia, thrombocytopenia, and 49% primitive cells in blood and 50% in bone marrow aspirate. Studies of cytochemical and immunologic markers ruled out a hematopoietic origin of the malignant cells. Laparotomy disclosed a pancreatic tumor which histological examination showed to be a pleomorphic giant cell carcinoma. The presented case is the first report of pleomorphic giant cell carcinoma of the pancreas which clinically manifested as acute leukemia.

Streszczenie

Karcynocytemia jest rzadkim powikłaniem złośliwych nowotworów narządowych polegającym na obecności komórek nowotworowych we krwi obwodowej, co przypomina obraz ostrej białaczki. Rak trzustki podobny do guza olbrzymiokomórkowego kości jest rzadką odmianą gruczolakoraka przewodowego trzustki o agresywnym przebiegu. 33−letni pacjent został przyjęty do Kliniki Hematologii z powodu niedokrwistości i małopłytkowości. We krwi obwodowej i szpiku stwierdzono obecność odpowiednio: 49 i 50% młodych komórek. Badania cytochemiczne i immunologiczne wykluczały pochodzenie komórek z układu krwiotwórczego. Podczas laparotomii stwierdzono guz trzustki, który morfologicznie odpowiadał rakowi trzustki podobnemu do guza olbrzymiokomórkowego kości. Przedstawiony przypadek jest pierwszym opisem raka trzustki podobnego do guza olbrzymiokomórkowego kości, którego pierwszym objawem były zmiany przypominające ostrą białaczkę.

Key words

carcinoma cell leukemia, carcinocythemia, osteoclastoma of pancreas, osteoclast−like giant cell tumor of the pancreas

Słowa kluczowe

karcynocytemia, rak trzustki podobny do guza olbrzymiokomórkowego kości

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