Advances in Clinical and Experimental Medicine

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Advances in Clinical and Experimental Medicine

2007, vol. 16, nr 1, January-February, p. 85–93

Publication type: review article

Language: English

Bioinformatics: From arduous beginnings to molecular databases

Bioinformatyka: od trudnych początków do molekularnych baz danych

Michał Piast1,, Irena Kustrzeba−Wójcicka1,, Małgorzata Matusiewicz1,, Małgorzata Krzystek−Korpacka1,, Teresa Banaś1,

1 Department of Medical Biochemistry, Silesian Piasts of Medicine in Wrocław, Poland

Abstract

This is a brief review of the origins of bioinformatics and the development of biological databases and molecular analysis tools. The paper covers the period from 1945 (Sanger’s work on insulin) to 2004 (introduction of the latest MEGA version, GenBank release 143). For the purpose of this article, the term “bioinformatics” means the discipline involving biology and computer science, and the term “computational biology” is understood as a process of biological data analysis and interpretation.

Streszczenie

Zwięzły opis początków bioinformatyki, rozwoju molekularnych baz danych i narzędzi do analizy sekwencji aminokwasowych i nukleotydowych. Praca obejmuje okres od roku 1945 (prace Sangera nad insuliną) do roku 2004 (wprowadzenie najnowszej wersji programu MEGA, aktualizacja bazy GenBank do wersji 143). Na potrzeby niniejszej pracy określenie „bioinformatyka” oznacza dyscyplinę łączącą biologię i nauki komputerowe, a termin „biologia obliczeniowa” jest rozumiany jako proces analizy i interpretacji danych biologicznych.

Key words

Software Databases, Evolution, Phylogenetics, Sequence alignment

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