Advances in Clinical and Experimental Medicine

Title abbreviation: Adv Clin Exp Med
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ISSN 1899–5276 (print), ISSN 2451-2680 (online)
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Advances in Clinical and Experimental Medicine

2007, vol. 16, nr 1, January-February, p. 149–154

Publication type: review article

Language: Polish

Niedrożność rzekoma

Intestinal pseudoobstruction

Ewa Waszczuk1,, Anna Susło1,, Leszek Paradowski1,

1 Katedra i Klinika Gastroenterologii i Hepatologii AM we Wrocławiu

Streszczenie

Niedrożność rzekoma jest bardzo rzadko rozpoznawanym zaburzeniem motoryki jelit. W jej przebiegu dochodzi do powtarzających się epizodów niedrożności, przy nieobecności mechanicznej przeszkody. Objawy różnią się w zależności od umiejscowienia i czasu trwania choroby, a należą do nich nudności, wymioty, zaparcia i bóle brzucha, mogące dawać nawet obraz kliniczny „ostrego brzucha”. Nie należy jej pomijać w rozpoznaniu różnicowym. W leczeniu wykorzystuje się antybiotyki, leki prokinetyczne i metody endoskopowe, zmniejszające ryzyko perforacji i pozwalające uniknąć interwencji chirurgicznej. W niektórych przypadkach jednak jest konieczna resekcja objętego procesem chorobowym fragmentu jelita lub transplantacja jelita cienkiego.

Abstract

Chronic intestinal pseudoobstruction (CIP) is a very rarely diagnosed intestinal motility disorder. It manifests as episodes of intestinal obstruction in the absence of true mechanical blockage. Symptoms vary depending on the location of involved segments and duration of the disease. A patient can have many different symptoms like nausea, vomiting, obstruction and abdominal pain, even manifests as “acute abdomen”. CIP should not be excluded in differential diagnose. Management strategies including antibiotics, prokinetic agents, endoscopic methods reduce the risk of perforation and help to avoid invasive procedures though same patients need resection of involved segments or even small intestinal transplantation.

Słowa kluczowe

niedrożność rzekoma, zaburzenia motoryki jelit, zaparcie

Key words

pseudoobstruction, intestinal motility disorders, obstruction

References (22)

  1. Kansu A, Ensari A, Kalayc AG, Girgin N: A very rare case of intestinal pseudoobstruction – familiar visceral myopathy type IV. Acta Paediatr 2000, 89, 733–736.
  2. Borgaonkar M, Lumb B: Acute on chronic intestinal pseudoobstruction responds to neostigmine. Dig Dis Sci 2000, 45, 1644–1647.
  3. Panganamamula KV, Parkman HP: Chronic Intestinal Pseudo−Obstruction. Curr Treat Options Gastroenterol 2005, 8, 3–11.
  4. Camilleri M: Chronic intestinal pseudo−obstruction. In: Chronic Gastrointestinal Disorders. Eds.: Corazziari E.; Messaggi. Milano 2000, 2nd. ed., 271–292.
  5. Huizinga JD, Faussone−Pellegrini MS: About the presence of interstitial cells of Cajal outside the musculature of the gastrointestinal tract. JCMM 2005, 9, 468–473.
  6. Huizinga JD: Frontiers in research into interstitial cells of Cajal. JCMM 2005, 9, 230–231.
  7. Jain D, Moussa K, Tandon M, Culpepper−Morgan J, Proctor DD: Role of interstitial cells of Cajal in motility disorders of the bowel. AJG 2003, 3, 618–624.
  8. Remorgida V, Ragni N, Ferrero S, Anserini P, Torelli P, Fulcheri E: The involvement of the interstitial Cajal cells and the enteric nervous system in bowel endometriosis. Hum Reprod 2004, 20, 264–271.
  9. Tong WD, Liu BH, Zhang LY, Xiong RP: Expression of c−kit messenger ribonucleic acid and c−kit protein in sigmoid colon of patients with slow transit constipation. Int J Colorectal Dis 2005, 20, 363–367.
  10. Thomsen L., Robinson TL, Lee JC: Interstitial cells of Cajal generate a rhythmic pacemaker current. Nat Med 1998, 4, 848–851.
  11. Flanagan JG, Leder P: The kit ligan, a cell surface molecule altered in steel mutant fibroblasts. Cell 1990, 63, 185–194.
  12. Williams DE, Eisenman J, Baird A et al.: Identification of a ligand for the c−kit protooncogene. Cell 1990, 63, 167–174.
  13. YardenY, Kuang WJ, Yang−Feng T: Human proto−oncogene c−kit: a new cell surface receptor tyrosine kinase for an unidentified ligand. EMBO J 1987, 6, 3341–3351.
  14. Hirsh EH, Brandenburg D, Hersh T, Brooks WS Jr: Chronic intestinal pseudo−obstruction. J Clin Gastroenterol 1981, 3, 247–254.
  15. Faber J, Finch A, Steinberg A, Steiner I: Familial intestinal pseudoobstruction dominated by a progressive neurologic disease at a young age. Gastroenterology 1987, 786–790.
  16. Mousa H, Hyman P, Cocjin J, Flores A, Di Lorenzo C: Long−term outcome of congenital intestinal pseudoobstruction. Dig Dis Sci 2002, 47, 2298–2305.
  17. Coulie B., Camilleri M.: Intestinal psuedo−obstruction. Annu Rev Med 1999, 50, 37–56.
  18. Laine L: Management of acute colonic pseudo−obstruction. NEJM 1999, 341, 192–194.
  19. Gibbons JC, Sullivan JF: Chronic idiopathic pseudo−obstructive bowel disease. Am J Gastroenterol 1978, 70, 306–313.
  20. Vilcea D, Vasile I: Chronic intestinal pseudoobstruction syndrome in adults. Chirurgia (Bucur) 2004, 99, 117–124.
  21. Sigurdsson L, Reyes J, Kocoshis SA, Mazariegos G: Intestinal transplantation in children with chronic intestinal pseudo−obstruction. Gut 1999, 45, 570–575.
  22. Fishbein TM, Kaufmann SS, Florman SS: Isolated intestinal transplantation: proof of clinical efficancy. Transplantation 2004, 76, 636–640.