Advances in Clinical and Experimental Medicine

Title abbreviation: Adv Clin Exp Med
JCR Impact Factor (IF) – 1.736
5-Year Impact Factor – 2.135
Index Copernicus  – 168.52
MEiN – 70 pts

ISSN 1899–5276 (print)
ISSN 2451-2680 (online)
Periodicity – monthly

Alzheimer’s disease pathophysiology

Advances in Clinical and Experimental Medicine

Adv Clin Exp Med

Impact Factor (JCR) – 1.736

Journal publishes high quality original articles, research in progress and reviews of recognized scientists that deal with all clinical and experimental medicine.

Call for submissions of an Expression of Interest for an Adv Clin Exp Med Special Collection on

Immune system as a key to Alzheimer’s disease pathophysiology

Age-related changes in the inflammatory profile and in immune cell function in the brain and periphery are observed. Strong evidence indicates that both innate and adaptive immune cells, as a source of inflammatory mediators, may contribute to systemic and central nervous system chronic inflammation, to culminate in dementia and Alzheimer's disease (AD). Neurodegenerative hallmarks and immune system stimuli like infection or injury likely combine to trigger and maintain persistent microglial activation and thus, brain inflammation. Understanding the connection between the immune system and the brain shows promise in obtaining a more effective AD prevention and therapy.

Topic and format

Adv Clin Exp Med is therefore seeking review papers for a Special Collection. These should focus on innate and adaptive immune system contribution in Alzheimer’s disease pathophysiology, and cover the following themes:

  • Central and peripheral immune system dysregulation;
  • Neuroinflammation and neuronal death;
  • Early and later glial cells activation;
  • Role of blood–brain barrier;
  • Chronic inflammation;
  • Chronic infections and immune response;
  • Immune system activation by microbiome.

Submission process

As a first step, we ask for submissions of an Expression of Interest with an Abstract of review outlining the themes above to Adv Clin Exp Med Section Editor: Prof. Jerzy Leszek ( or Dr Marta Sochocka ( The Section Editor jointly with the Editor-in-Chief will review all submissions and select those Authors who will be invited to submit a full paper. The submission process will then follow the regular Adv Clin Exp Med online process. All manuscripts will be sent to at least two independent reviewers.

Dates and fees

  • Submission of Expression of Interest until June 30, 2023 to Prof. Jerzy Leszek ( or Dr Marta Sochocka (;
  • Invitation to submit full paper by September 30, 2023;
  • Submission of full paper by January 31, 2024;
  • If accepted, Authors will be required to pay a fee of 700 EUR, to cover publication costs.

We are looking forward to a wide variety and truly global collection of papers and experiences to push knowledge of Alzheimer’s disease pathophysiology to the next level!