Advances in Clinical and Experimental Medicine

Title abbreviation: Adv Clin Exp Med
JCR Impact Factor (IF) – 1.736
5-Year Impact Factor – 2.135
Index Copernicus  – 168.52
MEiN – 70 pts

ISSN 1899–5276 (print)
ISSN 2451-2680 (online)
Periodicity – monthly

Instructions for Authors


The Editorial Board accepts for publication only manuscripts written in US English. Authors not entirely familiar with English usage are advised to seek assistance of an English speaker; correct style is the responsibility of the authors. The journal does not offer translation services.

Please note that this journal employs a article processing charge. More about the amount of this charge and waivers here. The journal offers no discounts, including discounts for lower-income countries.


Manuscripts may be considered for publication in the following sections:

  • Original papers – including experimental research;

  • Reviews;

  • Meta-Analyses; 

  • Research-in-Progress;

  • Editorials (by invitation only); 

  • Research letters. 

By reviews we understand various types of reviews listed here. Advances in Clinical and Experimental Medicine DOES NOT ACCEPT case reports. Priority will be given to original papers developed as part of international cooperation.

A research letter is a brief, but scientifically important study which is basically a shorter form of Original paper. The text structure (Background – Objectives – Material and methods – Discussion – Limitations – Conslusions) remains the same. Research letters are peer reviewed and subject to stringent editorial review as well. They are also indexed in all databases, including PubMed and Scopus, and the number of points assigned for such publication is identical as for original papers. However, a research letter contains a maximum of 1500 words, as opposed to 3500 words in an original article, and at most 2 tables or figures (2 tables and 2 figures at most in one paper). The number of authors and the number of references are not limited.


It is important to note that:

1) research letters are priority papers in our journal and the waiting time for publication is shorter;

2) the article processing charge is much lower than that for an Original paper (350 EUR/1750 PLN instead of 990 EUR/4900 PLN). 

Authors of Original papers considered by the editors too brief to be published as such will be asked to change the category of the manuscript into a Research letter.


The Editorial Office reserves the right to change the category of the manuscripts if its contents require it – e.g., from Original Paper into Meta-analysis or Research letter.

The submitted manuscripts should meet the general standards and requirements agreed upon by the International Committee of Medical Journal Editors, known as “Recommendations for the Conduct, Reporting, Editing, and Publication of Scholarly Work in Medical Journals”. They should also conform to the high-quality editorial procedures and practice (formulated by the Index Copernicus International Scientific Committee as Consensus Statement on Good Editorial Practice 2004).

If the article is already accessible online as registered preprint on any website or in any database, and has been already assigned with a DOI, such information, together with an URL of the registered preprint, has to appear in the cover letter.

All research presented in papers accepted for publication in Advances in Clinical and Experimental Medicine should be conducted in strict adherence to rules, guidelines, intenational conventions/declarations and other regulations pertaining research on humans, animals and cell lines.


Submission of manuscripts

All manuscripts should be submitted to Editorial Office via electronic Editorial System. WE DO NOT ACCEPT manuscripts sent by post or e-mail.

The manuscript should be anonymyzed – please remove all names and affiliations of the authors from the main text.

Should any conflict of interest arise, it should be reported while submitting the manuscript in a dedicated section of the submission procedure in our Editorial System. Information about funding sources should be reported while submitting the manuscript in a dedicated section of the submission procedure, not in the Acknowledgements section of this procedure.

Manuscripts which are not adequately prepared will be returned to the corresponding Author and rejected if we do not receive proper revisions within 30 days.

We have prepared a useful tool for the authors of our journal, including guidelines needed while working on a new article. We hope that provided instruction will address any of your concerns. Before uploading a new manuscript, read Stylebook in a Nutshell and get acquainted with all necessary information.



The authorship should be based on the following criteria:

  • Substantial contributions to the conception or design of the work; or the acquisition, analysis, or interpretation of data for the work;

  • Drafting the work or revising it critically for important intellectual content;

  • Final approval of the version to be published.

Authors should meet all three (3) above criteria. If a large, multi-center group conducted the research, the group should identify the individuals who accept direct responsibility for the manuscript. The Author submitting a collectively authored manuscript should establish the order of authorship, provide all individual authors of the particular group, as well as provide the group's name. All those designated as authors should meet all criteria for authorship, and all who meet the criteria should be identified as authors. The contribution of each Author must be documented to the extent to take the public responsibility for appropriate portions, the content and the conflict of interests. Authors who do not meet all three criteria of authorship should be acknowledged (prior to their written consent).

All Authors who have made significant contributions should be listed as co-authors and their authorship should be disclosed in accordance with the following list:

A – research concept and design; B – collection and/or assembly of data; C – data analysis and interpretation; D – writing the article; E – critical revision of the article; F – final approval of article.

Ghostwriting and guest authorship are manifestations of scientific misconduct, and any detected cases will be unmasked, including notification of the relevant entities (institutions employing the authors, scientific societies, associations, scientific editors, etc.). Editors require the identification of funding sources of publications, information about contribution to research from institutions, associations and other entities (the rule: financial disclosure). Editors continuously monitor and document any signs of scientific misconduct, especially violations and breaches of ethics applicable in the study. Please read our ethics statement.

Please note that there can be only 1 first Author and 1 corresponding Author for each manuscript (both functions can be also held by a single person). ACEM does not permit co-first authorship and co-corresponding Authors for any reasons. 


Changes to authorship

Before manuscript submission, provide the final and definite list of all authors. If you want to add, remove or change the order of the authors, you can do it only before the manuscript acceptance. Each change, however, should be always approved by the journal Editor.

To make authorship changes, send to the Editorial Office:

1. the reason for the change in the author list; and

2. a written signed consent (via e-mail/letter) from all authors stating that they agree with the addition, removal or rearrangement in the list.

We require such signatures from all authors, even those who have been added or removed. In exceptional circumstances our Editors can consider the addition, deletion or rearrangement of authors after the manuscript acceptance. Please note, however, that the process of publication will be suspended until Editors reach such a decision.

Changes of authorship following the acceptance of the manuscript for publications are not permitted.



Abstract of ORIGINAL PAPERS, META-ANALYSES and RESEARCH LETTERS should contain from 200 to 300 words and consist of 5 separate parts introduced by separate subheadings in the following order:

  • Background;

  • Objectives;

  • Materials and methods;

  • Results;

  • Conclusions.

An unstructured abstract of 150 to 250 words is required for REVIEWS.

Abstract should be only registered in the system – please, do not paste it into the main body of the paper.


Graphical abstract

Beginning with the 1/2023 issue, the journal Advances in Clinical and Experimental Medicine requires also visual abstracts (also known as graphical abstracts) for papers accepted for publication. Such abstract is a single, concise, pictorial and visual summary of the main findings of the article. It should be a figure that is specially designed for the purpose, which captures the content of the article for readers at a single glance. Authors must provide an original image that clearly represents the work described in the paper. Graphical abstracts should be submitted as a separate file in the submission system as Figure 0. For ease of browsing, the graphical abstract should have a clear start and end, preferably "reading" from top to bottom or left to right. Try to reduce distracting and cluttering elements as much as possible. No additional text, outline or synopsis should be included. Any text or label must be part of the image file. Please do not use unnecessary white space or a heading “graphical abstract” within the image file. The text within the graphical abstract should be used sparingly. The graphical abstract for a paper should not include data items of any type; all the content should be in a graphical form.

Allowed data formats: PDF, JPG PNG, and TIFF (min. 1200 pixels of the base in the drawing with the width of one column and 2400 for the width of two columns). The minimal resolution of tif, jpg and png files is 300 dpi. Regarding text within the graphical abstract, its size should be 12–16 points (smaller fonts will not be legible online).

A graphical abstract has to be read horizontally or circularly and have a rectangular, square or round shape. It cannot be a single column read from top to bottom.

The editorial office of Adv Clin Exp Med does not offer graphical or DTP services – the authors have to provide graphical abstracts in a finished form. Neither one of the figures from the manuscript (e.g., a graph or diagram) nor a PRISMA diagram cannot simultaneously serve as a graphical abstract).

The graphical abstract cannot exceed the size on one A4 page – it should be less complicated than, e.g., conference poster. Therefore, it shouldn’t contain tables, figures taken directly from the paper or whole paragraphs of text, as well as it cannot be compiled from tables and figures from the manuscript. It also must not include:

  • reference showing how the paper should be cited;
  • logotype of Wroclaw Medical University;
  • title of the journal;
  • cover of the journal.

More on how to prepare visual abstract (with examples):

More on how to prepare graphical abstract, more examples and an online tool to prepare it:

Should any questions arise, do not hesitate to contact the editorial office. Please send the graphical abstracts via e-mail at the e-mail address


Key words

Abstract should be followed by 3–5 key words written in the language of the manuscript and recommended by the Index Medicus Subject Headings (MeSH).


Main text

Manuscripts should be submitted in the following formats: doc, docx, rtf. 

The manuscripts – main text and reference list – should be formatted as follows: Times New Roman 12, spacing 1.5.

The total number of words in REVIEWS and META-ANALYSES should not exceed 7000 words (including main text, tables and figure legends, and excluding reference list), 3000 words in ORIGINAL PAPERS (including main text and figure legends, but excluding title page, abstract and references) and 1500 words in RESEARCH LETTERS.

We accept up to 6 tables/figures (2 figures and 2 tables in Research letters).

For Original papers and Research letters, the main body of the text should consist of the following sections introduced by separate subheadings in the following order:

  • Background;

  • Objectives;

  • Materials and methods;

  • Results;

  • Discussion;

  • Limitations of the study;

  • Conclusions.

For cohort, case-control, and cross-sectional studies within the Original papers category, the structure of the Materials and Methods sections should conform to the stipulations of the STROBE checklist (see below). For Reviews, the manuscript should contain an Introduction section at the beginning, and Limitations and Conclusions sections at the end, while the structure of the rest of the text should follow the natural order of discourse. For Meta-analyses, the structure of the Materials and Methods sections should conform to the stipulations of the PRISMA checklist (see below).

References to literature, figures and tables should be placed in the order of their citation in the text. The Author(s) should not use italics (apart from names of the genes and taxonomy), bold or underlined words in the texts. Please use only generic names of drugs. Laboratory values should be expressed using the International System of Units (SI). The Author(s) should provide a short title that does not exceed 45 characters and spaces. The Author(s) should disclose all financial and material support.

When the study involves humans or animals, please include the disclaimer about the approval of the bioethical committee or about the reason why such consent was waived.

When the study involves humans, please include a disclaimer about compliance with the Declaration of Helsinki or about the reason why the Declaration is not applicable, as well as information of informed consent provided by the subjects or lack thereof.


Statistical analysis

Please read thorougly and familiarize yourself with our new statistical guidelines. These requirements are to be followed closely.



In addition, when preparing the manuscript, it is obligatory to consider the structure of the article according to one of the checklists below:

It is obligatory to refer to the EQUATOR site as a reference in selecting the appropriate checklist for the study: A FILLED checklist needs to be uploaded in the Editorial System separately. Please not that especially the STROBE checklist has to be submitted in a fillable version and filled in.


Units of measure

Laboratory values should be expressed using the International System of Units (Le Système International d’Unités, SI). Temperatures are to be given in degrees Celsius. If conventional units are used, their SI equivalents should be provided in parentheses only at first mention in the text.



Abbreviations should not be used unless they appear at least 3 times in the text. Nonstandard abbreviations should be avoided. Do not use abbreviations in manuscript titles (except when space considerations require otherwise) or figure legends and table titles. In rare cases, when the abbreviation is more familiar than the expansion, the abbreviation alone can be used (e.g. DNA). Abbreviations without expansion can also be used for statistical terms listed in the Statistical analysis section below. All abbreviations used in the text should be explained in the article, not on a separate list.



Tables should be placed in separate files, not pasted into the main body of the text. References to Tables should be placed according to the sequence of citing them in the manuscript. Allowed formats: xls, xlsx, doc, docx. The same data should not be provided twice – both in the text and in the table, but only in the table, while the text should contain only a reference to a given table.



Figures should be placed in separate files,  not pasted into the main body of the text. Captions for the figures should be placed at the end of the main body of the text. References to Figures should be placed according to the sequence of citing them in the manuscript. Allowed data formats: for VECTOR graphics (charts, diagrams, etc.) – pdf, eps, ai, cdr (if the graphic was created using MS Office programs, source files of a given program are very helpful: doc, docx, ppt, pptx, xls, xlsx); for BITMAP graphics (photos, screenshots) - tif, jpg, png, bmp (min. 1000 pixels of the base in the drawing with the width of one column and 2100 for the width of two columns). The minimal resolution of TIFF, JPG and PNG files is 300 dpi.

If Authors used in the Work any figures, photographs, charts, tables, etc. which are not their work, and are protected by the copyright law, they shall be obliged to provide the Publisher with a written authorization to use such materials issued by the author’s economic rights holders. The Author is required to provide the source of all figures, photographs, charts, etc.

The maximal number of figures for a RESEARCH LETTER is 3. This is the maximal number of single chart/graphs/photographs; a panel containing of, e.g., 4 elements and numbered as Fig. 1 counts as 4 figures, not 1.


If any supplementary tables and/or figures (or supplementary material of any other kind) have been submitted at any stage of the manuscript submission or review (e.g., at the request of stistical reviewer), the author should state whether the aforementioned material is meant for publication or not.



The references should be consecutively numbered, not prepared in Harvard style. The reference list should be in the order of works being cited in the text, not in alphabetical order.

It is the responsibility of the authors to ensure the accuracy of all references according to AMA citation style. References should be limited only to the most recent positions and directly connected to the presented topic. References should be identified by Arabic numerals (withour parentheses) in superscript and numbered consecutively in the order in which they are first mentioned in the manuscript. Abbreviations for journal names should be cited according to Index Medicus. If a journal is not listed in Index Medicus, its full name should be given. If the cited work is available online, the DOI number should be given, and in the case of lack thereof – URL with the access date.  Reference to articles that are accepted for publication may be cited as "in press", whereas manuscripts that are still in preparation or submitted for publication should be referred to as "unpublished data". This journal should be cited in lists as Adv Clin Exp Med. The abbreviation et al. should be applied when there are more than 6 authors, but only the first 3 authors should be listed in such situations (e.g., Hu X, Chang J, Mao M, et al.).

Please do not paste the reference list into the main text – it should be submitted only as a separate file. Please provide DOI for all cited works. 


Originality check

As a part of the initial verification of the manuscript, each text is checked using anti-plagiarism software (iThenticate). Only manuscript with a Similarity Index (SI) lower than 30% will be accepted for further verification – those with SI od 30% or higher will be sent back to authors for rewrite. This applies also to papers being continuations or expansions of previous publications – re-using previously published text, e.g. in the Materials and methods section, is not an accepted solution.


Anonymous review

All manuscripts will be subject to a process of anonymous editorial review (the name of authors and their affiliations will be disclosed to the reviewers only when the review process is complete). In order to achieve this, the first page and the acknowledgements page will be removed from the manuscripts sent to reviewers. Manuscripts will be sent to at least 2 independent reviewers. The final decision on accepting the manuscript is made by the Editorial Board, reviews are only supporting this decision. The Editorial Board’s final evaluation of each article is based on criteria developed by the Committee on Publication Ethics (COPE).

In their response to peer reviewers and statistical reviewers, the authors should address the reviewer’s remarks point after point, and provide an answer to each remark separately.



Authors should keep a copy of their article, as proofs will be sent to them without the manuscript. Corrections to the proofs should be restricted to printer’s errors only. In order to maintain rapid publication, proofs should be returned via Editorial System within 48 hours after receipt. If the Publisher receives no response from the authors after 48 hours, the manuscript will not be published.

Please note that since October 1, 2021 after the article is published as ahead of print, it cannot be changed (which encompasses also affiliations and authors’ order). Such stipulation stems from requirements set by scientific databases in which the papers published in Advances in Clinical and Experimental Medicine are stored.