Advances in Clinical and Experimental Medicine

Title abbreviation: Adv Clin Exp Med
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ISSN 1899–5276 (print)
ISSN 2451-2680 (online)
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Advances in Clinical and Experimental Medicine

2020, vol. 29, nr 7, July, p. 893–897

doi: 10.17219/acem/121011

Publication type: review article

Language: English

License: Creative Commons Attribution 3.0 Unported (CC BY 3.0)

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Association between heparin-binding hemagglutinin and tuberculosis

Feifei Pu1,A,B, Jing Feng1,D,E, Ping Xia1,E,F

1 Hospital (Wuhan Integrated TCM & Western Medicine Hospital), Tongji Medical College, Huazhong University of Science and Technology, China


The current global burden of tuberculosis (TB) is one of the greatest challenges to public health, particularly in developing countries, and thus effective diagnostic methods and treatment options for TB remain a central topic in basic and clinical research. Heparin-binding hemagglutinin (HBHA)-specific immune responses have been linked to protection against TB. The binding of HBHA-coated beads to epithelial and endothelial cell layers may trigger transcytosis of the beads, which is the basis for extrapulmonary dissemination. In addition, HBHA has been confirmed as a potential diagnostic marker for TB, and it is important in developing new TB vaccines and anti-TB drugs. Recently, basic research on HBHA has been intensified. The HBHA application in the field of prevention and treatment should be further explored. In addition, the existing research achievements have shown its broad application prospects. Currently, there are no relevant specialized products, and research should be accelerated. These products may contribute to the application of HBHA in the diagnosis, prevention and treatment of TB.

Key words

heparin-binding hemagglutinin, tuberculosis, diagnosis, treatment

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