Advances in Clinical and Experimental Medicine
2020, vol. 29, nr 5, May, p. 581–585
Publication type: original article
License: Creative Commons Attribution 3.0 Unported (CC BY 3.0)
Evaluation of the association between angiotensin converting enzyme insertion/deletion polymorphism and the risk of endometrial cancer in and characteristics of Polish women
1 Institute of Medical Sciences, College of Medical Sciences, University of Rzeszów, Poland
2 Laboratory of Molecular Biology, Centre for Innovative Research in Medical and Natural Sciences, College of Medical Sciences, University of Rzeszów, Poland
3 Department of Pathology, Chair of Oncology, Medical University of Lodz, Poland
4 College of Medical Sciences, University of Rzeszów, Poland
5 Department of Gynecology and Obstetrics, Provincial Clinical Hospital No. 2 in Rzeszów, Poland
6 Institute of Health Sciences, College of Medical Sciences, University of Rzeszów, Poland
7 Gynecology and Obstetrics Clinic, Frederic Chopin Clinical Provincial Hospital No. 1, Rzeszów, Poland
Background. Endometrial cancer is the most common malignant neoplasm of the female reproductive organs. A dysfunctional endometrial renin-angiotensin system (RAS) might contribute to the growth and spread of endometrial cancer. The RAS-related gene polymorphisms, including the polymorphism of insertion/deletion (I/D) in the angiotensin-converting enzyme (ACE) gene, influence RAS activity.
Objectives. In the present study, we examined the association between the I/D polymorphism of the ACE gene and endometrial cancer risk in Polish women.
Material and Methods. Genotype analysis of the ACE I/D polymorphism was carried out using polymerase chain reaction (PCR) on 142 endometrial cancer type 1 patients and 68 cancer-free subjects. The results of the analyses were correlated with clinical data.
Results. The frequency of DD, DI and II ACE genotypes did not vary significantly between the experimental group and the control group (40 (28%), 61 (43%) and 41 (29%) vs 18 (26%), 31 (46%), and 19 (28%), respectively; p = 0.935). In addition, the incidence of the DD, DI and II polymorphisms in the ACE gene did not vary significantly between the experimental subgroups when stratified by cancer grade – G1, G2 and G3 endometrioid carcinoma – and the control group. Furthermore, the ACE polymorphism was not significantly associated with hypertension, diabetes or lymph node metastasis.
Conclusion. The ACE I/D gene polymorphism was not associated with endometrial cancer risk or the clinicopathological features in Polish women.
endometrial cancer, molecular biology, ACE gene polymorphism
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