Advances in Clinical and Experimental Medicine

Title abbreviation: Adv Clin Exp Med
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ISSN 2451-2680 (online)
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Advances in Clinical and Experimental Medicine

2020, vol. 29, nr 1, January, p. 157–163

doi: 10.17219/acem/112613

Publication type: review

Language: English

License: Creative Commons Attribution 3.0 Unported (CC BY 3.0)

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Palmoplantar pustulosis: Factors causing and influencing the course of the disease

Magdalena Putra-Szczepaniak1,A,C,D, Joanna Maj1,B,C,E, Alina Jankowska-Konsur1,B,C,E, Anna Czarnecka2,3,C,D, Anita Hryncewicz-Gwóźdź1,A,C,D,F

1 Clinic of Dermatology, Venereology and Allergology, Wroclaw Medical University, Poland

2 Regional Specialist Hospital, Research and Development Centre, Wrocław, Poland

3 Faculty of Physiotherapy, University School of Physical Education, Wrocław, Poland


Palmoplantar pustulosis (PPP) is a chronic inflammatory disease, most often occurring in middle-aged women. In the course of the condition, painful skin lesions appear on the hands and feet, i.e., areas that are extremely important in everyday life. Therefore, the disease significantly reduces quality of life. The pathogenesis of this disease is poorly understood, although it is known that genetic, immunological and environmental factors play a role in its development. Clinical observations confirm the role of nicotine and contact allergens in the development of the lesions. The skin lesions can also occur as a side effect of certain medications. In some cases, PPP coexists with other diseases, i.e., seronegative arthropathies, as well as celiac and thyroid diseases. There is also a connection between the disease and infectious bacterial foci. Exacerbation of the skin lesions is triggered by stress. Therefore, patients require multidirectional tests, since finding the cause of the disease is essential to administering effective treatment.

Key words

etiopathogenesis, palmoplantar pustulosis, exacerbating factors

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