Advances in Clinical and Experimental Medicine

Title abbreviation: Adv Clin Exp Med
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ISSN 1899–5276 (print)
ISSN 2451-2680 (online)
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Advances in Clinical and Experimental Medicine

2018, vol. 27, nr 3, March, p. 313–319

doi: 10.17219/acem/64937

Publication type: original article

Language: English

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The correlation between pancreatic dysfunction markers and selected indices of periodontitis

Andrzej Miskiewicz1,A,B,C,D,E,F, Grzegorz Szparecki2,B,C,D, Marek Durlik3,A,B,D,E, Grażyna Rydzewska4,A,B,D,E, Ireneusz Ziobrowski3,A,B,E, Renata Górska1,A,B,C,D,E,F

1 Department of Periodontology and Oral Diseases, Medical University of Warsaw, Poland

2 Department of Pathology, Medical University of Warsaw, Poland

3 Department of Gastroenterological Surgery and Transplantation, Central Clinical Hospital of the Ministry of Internal Affairs, Warszawa, Poland

4 Department of Internal Medicine and Gastroenterology with Inflammatory Bowel Diseases Unit, Central Clinical Hospital of the Ministry of Internal Affairs, Warszawa, Poland

Abstract

Background. Periodontitis is a major risk factor of systemic diseases with inflammatory etiology. Numerous studies have established the connection between periodontal condition and diabetes, but there are no reports in the literature on the relationship between periodontitis and other pancreas conditions. The activity of pancreatic enzymes is an important parameter of pancreatic damage, and is also a diagnostic marker of acute and chronic pancreatitis, and the bleeding index determines the periodontitis activity. To date, the periodontal status in both of the above-mentioned conditions has not been examined.
Objectives. The objective of the study was to provide a clinical evaluation of oral cavity hygiene and the condition of periodontal tissues in patients diagnosed with pancreatic adenocarcinoma or chronic pancreatitis and in the control group, and to assess the correlation between the activity of periodontitis and the concentration of glycated hemoglobin HbA1c, lipase activity and pancreatic amylase in serum from the examined groups.
Material and Methods. The serum activity levels of amylase, lipase and HbA1c concentration were correlated with periodontitis activity markers in patients diagnosed with chronic pancreatitis (n = 41), pancreatic cancer (n = 29) and in the control group (n = 50).
Results. In the group with chronic pancreatitis, we have found a positive association between the bleeding on probing (BOP) and the amylase activity (r = 0.64) as well as the lipase (r = 0.62; p < 0.05). The patients diagnosed with pancreatic cancer evinced a higher value of the inflammatory response index, namely 1.51, than the other studied groups (H = 24.94; p = 0.01). Patients diagnosed with chronic pancreatitis evinced the highest periodontitis activity indices: BOP: 62.53% (H = 61.31; p = 0.01) and probing depth (PD): 4.14 ±0.89 mm (H = 22.43; p < 0.0001).
Conclusion. The study showed that periodontitis in patients with pancreatic cancer is independent of the state of oral hygiene. In the group of patients with chronic pancreatitis, the observed positive correlation between the bleeding index and the enzyme activity suggests interaction between the examined diseases.

Key words

chronic pancreatitis, periodontitis, pancreatic cancer

References (17)

  1. Michaud DS. Epidemiology of pancreatic cancer. Minerva Chir. 2004; 59:99–111.
  2. Yadav D, Lowenfels AB. The epidemiology of pancreatitis and pancreatic cancer. Gastroenterology. 2013;144:1252–1261.
  3. Bilimoria K, Bentrem DJ, Ko CY, Stewart AK, Winchester DP, Talamonti MS. National failure to operate on early stage pancreatic cancer. Ann Surg. 2007;246:173–180.
  4. Yang AL, Vadhavkar S, Singh G, Omary M. Epidemiology of alcohol-related liver and pancreatic disease in the United States. Arch Intern Med. 2008;168:649–656.
  5. Zhang L, Farrell JJ, Zhou H, et al. Salivary transcriptomic biomarkers for detection of resectable pancreatic cancer. Gastroenterology. 2010;138:949–957.
  6. Wong DT, Zhang J, Farrell J, et al. Salivary biomarkers for pancreatic cancer detection. J Clin Oncol. 2009;27(Suppl 15S):4630.
  7. Camen GC, Caraivan O, Olteanu M, et al. Inflammatory reaction in chronic periodontopathies in patients with diabetes mellitus: Histological and immunohistochemical study. Rom J Morphol Embryol. 2012;53:55–60.
  8. Yoon AJ, Cheng B, Philipone E, Turner R, Lamster IB. Inflammatory biomarkers in saliva: Assessing the strength of association of diabetes mellitus and periodontal status with the oral inflammatory burden. J Clin Periodontol. 2012;39:434–440.
  9. Wong JC, Raman S. Surgical resectability of pancreatic adenocarcinoma: CTA. Abdom Imaging. 2010;35:471–480.
  10. Etemad B, Whitcomb DC. Chronic pancreatitis: Diagnosis, classification, and new genetic developments. Gastroenterology. 2001;120: 682–707.
  11. Tanaka S, Nakaizumia A, Ioka T, et al. Main pancreatic duct dilatation: A sign of high risk for pancreatic cancer. Jpn J Clin Oncol. 2002;68: 237–242.
  12. Petrone MC, Arcidiacono PG, Testoni PA. Endoscopic ultrasonography for evaluating patients with recurrent pancreatitis. World J Gastroenterol. 2008;14:1016–1022.
  13. Mombelli A. Clinical parameters: Biological validity and clinical utility. Periodontol 2000. 2005;39:30–39.
  14. Nathan DM, Kuenen J, Borg R, et al. Translating the A1C assay into estimated average glucose values. Diabetes Care. 2008;31:1473–1478.
  15. Wali JA, Masters SL, Thomas HE. Linking metabolic abnormalities to apoptotic pathways in Beta cells in type 2 diabetes. Cells. 2013;2: 266–283.
  16. Yin Y, Pastrana JL, Li X, et al. Inflammasomes: Sensors of metabolic stresses for vascular inflammation. Front Biosci. 2013;18:638–649.
  17. Kornman KS, Crane A, Wang HY, et al. The interleukin-1 genotype as a severity factor in adult periodontal disease. J Clin Periodontol. 1997;24:72–77.
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