Advances in Clinical and Experimental Medicine

Title abbreviation: Adv Clin Exp Med
JCR Impact Factor (IF) – 1.736
5-Year Impact Factor – 2.135
Index Copernicus  – 168.52
MEiN – 70 pts

ISSN 1899–5276 (print)
ISSN 2451-2680 (online)
Periodicity – monthly

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Advances in Clinical and Experimental Medicine

2018, vol. 27, nr 11, November, p. 1555–1560

doi: 10.17219/acem/75147

Publication type: original article

Language: English

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Vitamin D, cardiovascular and bone health in postmenopausal women with metabolic syndrome

Jolanta Dadoniene1,2,A,C,D, Alma Čypienė2,3,B,C, Egidija Rinkūnienė2,3,B,C,D, Jolita Badariene2,3,B,C, Aleksandras Laucevičius2,3,A,E,F

1 Institute of Health Sciences, Faculty of Medicine, Vilnius University, Lithuania

2 State Research Institute for Innovative Medicine, Vilnius, Lithuania

3 Centre of Cardiology and Angiology, Vilnius University Hospital, Lithuania


Background. The evidence highlights the importance of improving vitamin D levels in the general population for the prevention of adverse long-term health risks, including cardiovascular events, metabolic syndrome, cancer, anxiety and depression, and overall mortality, although controversies in the research are common.
Objectives. The purpose of this study was to investigate the relationship between vitamin D and vascular and bone health among postmenopausal metabolic women, controlling for traditional cardiovascular factors, and thus seeking to explore their plausible relation. The secondary aim was to look specifically for the relation between artery stiffness and bone health.
Material and Methods. This is a cross-sectional study designed to evaluate the relation between vitamin D level and vascular and bone health among women with metabolic syndrome. Two hundred and ten women visiting a cardiologist were recruited consecutively into the study. The study variables included clinical examination, laboratory findings, measurements of vascular stiffness, and bone turnover markers.
Results. We found 126 (60%) metabolic women with a vitamin D deficiency (50 nmol/L) among the study group. We discovered no statistically significant correlation between vitamin D and vascular stiffness. Vitamin D was not associated neither with femoral neck bone mineral density (BMD) and T score, nor with lumbar spine BMD and T score. Nevertheless, there was an indirect weak correlation between vascular stiffness, in particular the augmentation index (AIx), and all bone health markers, including BMD and T score in both the femur head and lumbar spine.
Conclusion. We showed a high proportion of postmenopausal metabolic women with a vitamin D deficiency, but there was no relation between vitamin D and vascular health or vitamin D and bone health. Nevertheless, the relation between vascular health and bone health exists, although the role of vitamin D in this link has not yet been established.

Key words

metabolic syndrome, vitamin D, bone mineral density, vascular stiffness

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