Advances in Clinical and Experimental Medicine

Title abbreviation: Adv Clin Exp Med
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Index Copernicus  – 161.11; MEiN – 140 pts

ISSN 1899–5276 (print)
ISSN 2451-2680 (online)
Periodicity – monthly

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Advances in Clinical and Experimental Medicine

2016, vol. 25, nr 3, May-June, p. 493–503

doi: 10.17219/acem/59349

Publication type: original article

Language: English

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The Efficacy of Perioperative Antibiotic Therapy in Tonsillectomy Patients

Krzysztof Orłowski1,B,C,D, Grażyna Lisowska1,D,E,F, Hanna Misiołek2,B,E,F, Zbigniew Paluch1,B,E,F, Maciej Misiołek1,A,C

1 Department of Otorhinolaryngology and Laryngological Oncology in Zabrze, Medical University of Silesia, Katowice, Poland

2 Department of Anesthesiology and Intensive Therapy in Zabrze, Medical University of Silesia, Katowice, Poland


Background. While the results of early research suggested that perioperative antibiotic prophylaxis in tonsillectomy patients is associated with many benefits, these data were not confirmed by further studies and meta-analyses.
Objectives. The aim of this study was to investigate the usefulness and efficacy of antibiotic monotherapy in the healing of surgical wounds of patients undergoing bilateral resection of the palatine tonsils, based on an analysis of selected objective and subjective characteristics of wound healing during the postoperative period.
Material and Methods. The study included 50 men and women who underwent routine resection of the palatine tonsils. The patients were randomized into two groups: Group I, undergoing tonsillectomy with cefuroxime prophylaxis (n = 25), and Group II, who were not given perioperative antibiotic therapy (n = 25). The severity of signs and complaints recorded on postoperative days 1–10 was scored on 3- and 10-item scales.
Results. The only significant intergroup differences pertained to problems with swallowing food and fluids on postoperative days 4–6, 8 and 9 (less prevalent in Group II), postoperative use of analgesics on postoperative day 9 (less frequent in Group II), the degree of mucosal swelling in the operated area on postoperative days 3 and 7 (less severe in Group II), and the amount of fibrin covering the tonsillar niches on the third postoperative day (significantly higher in Group I).
Conclusion. The administration of antibiotics for prevention or control of infection should be preceded by a comprehensive analysis of the potential benefits and risks. Perioperative use of antibiotics is justified only in selected cases, i.e. in individuals with comorbidities.

Key words

antibiotics, prophylaxis, tonsillectomy, wound healing

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