Advances in Clinical and Experimental Medicine

Title abbreviation: Adv Clin Exp Med
JCR Impact Factor (IF) – 1.736
5-Year Impact Factor – 2.135
Index Copernicus  – 168.52
MEiN – 70 pts

ISSN 1899–5276 (print)
ISSN 2451-2680 (online)
Periodicity – monthly

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Advances in Clinical and Experimental Medicine

2015, vol. 24, nr 4, July-August, p. 679–686

doi: 10.17219/acem/33009

Publication type: review article

Language: English

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Acrylic Resin Cytotoxicity for Denture Base – Literature Review

Marcelo C. Goiato1,A,F, Emily Freitas1,B,D, Daniela dos Santos1,E, Rodrigo de Medeiros2,C, Mariana Sonego2,B,D

1 1st Department of Dental Materials and Prosthodontics, Aracatuba Dental School, UNESP – Universidade Estadual Paulista “Júlio de Mesquita Filho”, Araçatuba, Sao Paulo, Brazil

2 Department of Dental Materials and Prosthodontics, Aracatuba Dental School, UNESP – Universidade Estadual Paulista “Júlio de Mesquita Filho”, Araçatuba, Sao Paulo, Brazil


Acrylic resin is a widely used material in clinical practice, and a satisfactory biocompatibility is essential. When the resin polymerization reaction is incomplete, residual monomers are released into the oral cavity. The aim of this study was to evaluate, through a literature review, the cytotoxicity caused by the denture base acrylic resin used, and its components. The selection of published studies was performed on the Pubmed database from January 2008 to July 2013. The keywords used were: “cytotoxicity and acrylic resins”, “cytotoxicity and denture base resins” and “cytotoxicity and oral prosthesis”. Inclusion criteria were: in vitro studies and literature reviews published in English that evaluated the acrylic resin cytotoxicity for denture base and its components. Studies with no reference to the search strategy were excluded. A total of 182 articles were found. Among these, only 13 were included for writing this review. The MTT test is the most common test used to evaluate acrylic resin cytotoxicity. Auto-polymerized resin is more cytotoxic than heat-polymerized resin because of its higher quantity of residual monomers which cause cell and tissue changes in the oral mucosa. However, more studies are necessary for the development of biocompatible materials.

Key words

acrylic resins, cytotoxicity tests, biocompatibility testing.

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