Advances in Clinical and Experimental Medicine

Title abbreviation: Adv Clin Exp Med
JCR Impact Factor (IF) – 1.736
5-Year Impact Factor – 2.135
Index Copernicus  – 168.52
MEiN – 70 pts

ISSN 1899–5276 (print)
ISSN 2451-2680 (online)
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Advances in Clinical and Experimental Medicine

2006, vol. 15, nr 6, November-December, p. 1129–1138

Publication type: review article

Language: English

Low Molecular Weight Biomarkers in the Nephrotoxicity

Niskocząsteczkowe wskaźniki biochemiczne w diagnostyce nefrotoksyczności

Zofia Marchewka1,

1 Chair and Department of Toxicology, Laboratory of Environmental Nephrotoxicity Markers, Silesian Piasts University of Medicine, Wrocław, Poland

Abstract

The autor presents function and the diagnostics significance of urinary low molecular weight proteins and enzymes to evaluate kidney function. The markers, which allow to evaluate the function of the most sensitive renal tubules on the xenobiotics action, were chosen. They are: annexin V, α1−microglobulin (α1M), Clara cell protein (CC16), retinol binding protein (RBP), β2−microglobulin (β2M), cystatin C, lysozyme, lipocalin.

Streszczenie

W pracy przedstawiono funkcję i wartość diagnostyczną białek i enzymów niskocząsteczkowych w ocenie czynności nerek. Wybrano wskaźniki pozwalające ocenić stan i funkcję cewek nerkowych najbardziej wrażliwych na działanie ksenobiotyków. Do wskaźników tych należą: aneksyna V, α1−mikroglobulina (α1M), białko komórek Clara (CC16), białko wiążące retinol (RBP), β2−mikroglobulina (β2M), cystatyna C, lizozym, ludzka obojętnochłonna lipokalina (HNL).

Key words

nephrotoxicity, early markers, urine analysis

Słowa kluczowe

nefrotoksyczność, wczesne markery, analiza moczu

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