Advances in Clinical and Experimental Medicine

Title abbreviation: Adv Clin Exp Med
JCR Impact Factor (IF) – 1.736
5-Year Impact Factor – 2.135
Index Copernicus  – 168.52
MEiN – 70 pts

ISSN 1899–5276 (print)
ISSN 2451-2680 (online)
Periodicity – monthly

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Advances in Clinical and Experimental Medicine

2006, vol. 15, nr 3, May-June, p. 497–503

Publication type: review article

Language: Polish

Komórki niezróżnicowane – źródła i plastyczność

Stem Cells – Sources and Plasticity

Dorota M. Olszewska−Słonina1,, Jan Styczyński2,, Tomasz A. Drewa1,, Rafał Czajkowski1,

1 Katedra Biologii Medycznej UMK w Toruniu, CM w Bydgoszczy

2 Katedra i Klinika Pediatrii, Hematologii i Onkologii UMK w Toruniu, CM w Bydgoszczy

Streszczenie

Komórki pnia zostały zidentyfikowane na przełomie lat 40. i 50. XX w. podczas badania skutków, jakie wywiera promieniowanie jonizujące na zwierzęta. Komórki macierzyste są niezróżnicowane, charakteryzują się różną zdolnością do samoodtwarzalności, proliferacji i różnicowania. Zdając sobie sprawę z właściwości biologicznych komórek macierzystych, rozważa się możliwość stosowania terapii komórkowej, zwanej regeneracyjną. Stwierdzono, że komórki macierzyste mogłyby być podstawą leczenia regeneracyjnego, które odegrałoby olbrzymią rolę w chorobie Parkinsona, cukrzycy, niektórych zaburzeniach neurologicznych z chorobami demielinizacyjnymi, takimi jak: stwardnienie rozsiane, choroba Alzheimera i leukodystrofie włącznie, oraz w regeneracji uszkodzonego mięśnia sercowego. Doświadczenia zdobyte w dziedzinie biologii komórek macierzystych zapowiadają również rozwój terapii białkowej i molekularnej wykorzystującej białka i małe cząstki w celu pobudzenia własnych komórek macierzystych do naprawy i odnowy.

Abstract

Stem cells were identified in forties and fifties of XX century during the studies on influence of ionizing radiation on animals. They are characterized by self−renewal potential, and ability to proliferate and differentiate. Due to biological properties of stem cells, the possibility of regenerative cell therapy is considered. Stem cells culture is a promising and pragmatic approach for repairing the damaged tissues and organs. The availability of human stem cells provide exciting possibilities for the treatment of many human diseases including Parkinson disease, diabetes mellitus, damaged heart muscle, neurological disorders involving demyelination such as multiple sclerosis, Alzheimer’s disease and leukodystrophies. Experience on biology of stem cells announce progress of the protein and molecular therapy which take advantage of proteins and small particles in the aim to induce host stem cells reparation and regeneration.

Słowa kluczowe

embrionalne komórki pnia, hodowla tkankowa, różnicowanie, medycyna regeneracyjna

Key words

embryonic stem cells, tissue culture, differentiation, regenerative medicine

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