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TY - JOUR
JO - Advances in Clinical and Experimental Medicine
J2 - Adv Clin Exp Med
SN - 1899-5276
PB - Wroclaw Medical University
VL - 26
IS - 7
PY - 2017
ID - Durmuş2017-10-31
TI - Histopathological evaluation of the effect of locally administered strontium on healing time in mandibular fractures: An experimental study
AB - Background. Mandibular fractures are the most common facial fractures. They can be treated by conservative techniques or by surgery. The authors hypothesized that the application of a single local dose of strontium chloride would accelerate the healing of subcondylar mandibular fractures, shorten the recovery time and prevent complications.Objectives. The aim of the present pilot study was to evaluate the effects of a single local dose of strontium chloride on the healing of subcondylar mandibular fractures in rats.Material and Methods. This randomized experimental study was carried out on 24 male Wistar albino rats. The rats were randomly divided into 3 groups: experimental group 1, receiving 3% strontium chloride; experimental group 2, receiving 5% strontium chloride; and the control group. A full thickness surgical osteotomy was created in the subcondylar area. A single dose of strontium solution (0.3 cc/site) was administered locally by injection on the bone surfaces of the fracture line created. Nothing was administered to the control group. The mandibles were dissected on postoperative day 21. The fractured hemimandibles were submitted to histopathological examination.Results. The median bone fracture healing score was 9 (range: 7–9) in experimental group 1; 8 (range: 7–10) in experimental group 2; and 7.50 (range: 7–8) in the control group. When the groups were compared in terms of bone healing scores, there was a statistically significant difference between experimental group 1 and the control group (p < 0.05).Conclusion. This study is the first to show that local strontium may have positive effects on the healing of subcondylar mandibular fractures. In the authors' opinion, 3% strontium was beneficial for accelerating facial skeleton consolidation and bone regeneration in rat subcondylar mandibular fractures. This treatment procedure may be combined with closed fracture treatment or a conservative approach.
AU - Durmuş, Kasım
AU - Turgut, Nergiz Hacer
AU - Doğan, Mehtap
AU - Tuncer, Ersin
AU - Özer, Hatice
AU - Altuntaş, Emine Elif
AU - Akyol, Melih
SP - 1063
EP - 1067
DA - 2017-10-31
DO - 10.17219/acem/65477
UR - http://dx.doi.org/10.17219/acem/65477
ER -