Deprecated: Constant FILTER_SANITIZE_STRING is deprecated in /home/srv55653/domains/advances.umw.edu.pl/public_html/cytowania/index.php on line 40

Deprecated: Constant FILTER_SANITIZE_STRING is deprecated in /home/srv55653/domains/advances.umw.edu.pl/public_html/cytowania/index.php on line 49

Deprecated: Constant FILTER_SANITIZE_STRING is deprecated in /home/srv55653/domains/advances.umw.edu.pl/public_html/cytowania/index.php on line 59

Warning: Cannot modify header information - headers already sent by (output started at /home/srv55653/domains/advances.umw.edu.pl/public_html/cytowania/index.php:40) in /home/srv55653/domains/advances.umw.edu.pl/public_html/cytowania/index.php on line 208

Warning: Cannot modify header information - headers already sent by (output started at /home/srv55653/domains/advances.umw.edu.pl/public_html/cytowania/index.php:40) in /home/srv55653/domains/advances.umw.edu.pl/public_html/cytowania/index.php on line 209

Warning: Cannot modify header information - headers already sent by (output started at /home/srv55653/domains/advances.umw.edu.pl/public_html/cytowania/index.php:40) in /home/srv55653/domains/advances.umw.edu.pl/public_html/cytowania/index.php on line 210

Warning: Cannot modify header information - headers already sent by (output started at /home/srv55653/domains/advances.umw.edu.pl/public_html/cytowania/index.php:40) in /home/srv55653/domains/advances.umw.edu.pl/public_html/cytowania/index.php on line 211

Warning: Cannot modify header information - headers already sent by (output started at /home/srv55653/domains/advances.umw.edu.pl/public_html/cytowania/index.php:40) in /home/srv55653/domains/advances.umw.edu.pl/public_html/cytowania/index.php on line 212

Warning: Cannot modify header information - headers already sent by (output started at /home/srv55653/domains/advances.umw.edu.pl/public_html/cytowania/index.php:40) in /home/srv55653/domains/advances.umw.edu.pl/public_html/cytowania/index.php on line 213
TY - JOUR JO - Advances in Clinical and Experimental Medicine J2 - Adv Clin Exp Med SN - 1899-5276 PB - Wroclaw Medical University VL - 34 IS - 4 PY - 2025 ID - Karolak2025-04-28 TI - Plasma N-terminal pro-brain natriuretic peptide concentrations may help to identify patients with very low-risk acute pulmonary embolism: A preliminary study AB - Background. Patients with an acute pulmonary embolism (APE) are a heterogeneous group, and some of them may benefit from early discharge and an ambulatory care referral. We aimed to evaluate the use of N-terminal pro-brain natriuretic peptide (NT-proBNP) plasma level assessment in patients with low-risk APE based on clinical findings (0 points on the simplified Pulmonary Embolism Severity Index (sPESI)).Material and Methods. Preliminary analysis of an ongoing prospective study including 1,151 normotensive patients with at least a segmental APE. In the final analysis, 348 patients with a 0-point sPESI were included. Blood samples were collected within the first 24 h of admission. The clinical endpoint (CE) included APE-related mortality and/or rescue thrombolysis in patients with clinical deterioration.Results. Clinical endpoints occurred in 3 patients who had higher plasma NT-proBNP levels than study participants with a favorable clinical course (164 [64–650] pg/mL compared to 2,930 [2,285.5–13,965] pg/mL; p = 0.01). Receiver operating characteristic (ROC) analysis showed that the area under the curve (AUC) for NT-proBNP for the prediction of the CEs was 0.918 (95% confidence interval [95% CI]: 0.831–1.00; p = 0.013). We defined the cutoff value of NT-proBNP at ≥1,641 pg/mL.Conclusion. Among subjects with 0 points on the sPESI, those with concentrations of NT-proBNP exceeding 1,641 pg/mL might require closer attention; remaining patients could be considered candidates for outpatient treatment. However, these findings warrant further investigation in a large, prospective group of patients. AU - Karolak, Bartosz AU - Skowrońska, Marta AU - Machowski, Michał AU - Dzikowska-Diduch, Olga AU - Bienias, Piotr AU - Kuryła, Martyna AU - Wiśniewska, Małgorzata AU - Gołębiowski, Marek AU - Pruszczyk, Piotr AU - Ciurzyński, Michał SP - 605 EP - 611 DA - 2025-04-28 DO - 10.17219/acem/187187 UR - http://dx.doi.org/10.17219/acem/187187 ER -