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@Article{Kurkinen2023-09-28,
author={Kurkinen, Markku},
title={Lecanemab (Leqembi) is not the right drug for patients with Alzheimer’s disease},
title={Lecanemab (Leqembi) is not the right drug for patients with Alzheimer’s disease},
journal={Advances in Clinical and Experimental Medicine},
year={2023},
volume={32},
number={9},
pages={943--947},
month={09},
day={28},
publisher={Wroclaw Medical University},
abstract={On July 6, 2023, the U.S. Food and Drug Administration (FDA) approved lecanemab (Leqembi) for the treatment of Alzheimer&rsquo;s dementia (AD) patients. In 2 clinical trials, lecanemab reduced amyloid in the brain and slowed cognitive decline. Here, I review in detail the clinical trial by van Dyck et al. (2023) entitled &ldquo;Lecanemab in early Alzheimer&rsquo;s disease&rdquo;, published in The New England Journal of Medicine on January 5, 2023. In this 18-month trial, lecanemab did not slow cognitive decline in women. This is especially significant because women have a twofold increased risk of AD compared to men, that is, there are 2 times more women than men living with AD. Lecanemab did not slow cognitive decline in APOE4 carriers; rather, it enhanced the decline in study participants with 2 APOE4 genes. This is bad news for AD patients, 60&ndash;75% of whom carry at least 1 APOE4 gene. These negative results regarding lecanemab&rsquo;s therapeutic value make me wonder if the approval of lecanemab was the worst decision of the FDA up till now, after the approval of aducanumab on June 7, 2021.},
issn={1899-5276},
doi={10.17219/acem/171379},
url={http://dx.doi.org/10.17219/acem/171379},